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DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics

Epigenetics deals with the interactions between genes and the immediate cellular environment. These interactions go a long way in shaping up each and every person's individuality. Further, reversibility of epigenetic interactions may offer a dynamic control over the expression of various critic...

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Autores principales: Bhattacharjee, Dipanjan, Shenoy, Smita, Bairy, Kurady Laxminarayana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826949/
https://www.ncbi.nlm.nih.gov/pubmed/27119045
http://dx.doi.org/10.1155/2016/6072357
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author Bhattacharjee, Dipanjan
Shenoy, Smita
Bairy, Kurady Laxminarayana
author_facet Bhattacharjee, Dipanjan
Shenoy, Smita
Bairy, Kurady Laxminarayana
author_sort Bhattacharjee, Dipanjan
collection PubMed
description Epigenetics deals with the interactions between genes and the immediate cellular environment. These interactions go a long way in shaping up each and every person's individuality. Further, reversibility of epigenetic interactions may offer a dynamic control over the expression of various critical genes. Thus, tweaking the epigenetic machinery may help cause or cure diseases, especially cancer. Therefore, cancer epigenetics, especially at a molecular level, needs to be scrutinised closely, as it could potentially serve as the future pharmaceutical goldmine against neoplastic diseases. However, in view of its rapidly enlarging scope of application, it has become difficult to keep abreast of scientific information coming out of various epigenetic studies directed against cancer. Using this review, we have attempted to shed light on two of the most important mechanisms implicated in cancer, that is, DNA (deoxyribonucleic acid) methylation and histone modifications, and their place in cancer pathogenesis. Further, we have attempted to take stock of the new epigenetic drugs that have emerged onto the market as well as those in the pipeline that offer hope in mankind's fight against cancer.
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spelling pubmed-48269492016-04-26 DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics Bhattacharjee, Dipanjan Shenoy, Smita Bairy, Kurady Laxminarayana Scientifica (Cairo) Review Article Epigenetics deals with the interactions between genes and the immediate cellular environment. These interactions go a long way in shaping up each and every person's individuality. Further, reversibility of epigenetic interactions may offer a dynamic control over the expression of various critical genes. Thus, tweaking the epigenetic machinery may help cause or cure diseases, especially cancer. Therefore, cancer epigenetics, especially at a molecular level, needs to be scrutinised closely, as it could potentially serve as the future pharmaceutical goldmine against neoplastic diseases. However, in view of its rapidly enlarging scope of application, it has become difficult to keep abreast of scientific information coming out of various epigenetic studies directed against cancer. Using this review, we have attempted to shed light on two of the most important mechanisms implicated in cancer, that is, DNA (deoxyribonucleic acid) methylation and histone modifications, and their place in cancer pathogenesis. Further, we have attempted to take stock of the new epigenetic drugs that have emerged onto the market as well as those in the pipeline that offer hope in mankind's fight against cancer. Hindawi Publishing Corporation 2016 2016-03-28 /pmc/articles/PMC4826949/ /pubmed/27119045 http://dx.doi.org/10.1155/2016/6072357 Text en Copyright © 2016 Dipanjan Bhattacharjee et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bhattacharjee, Dipanjan
Shenoy, Smita
Bairy, Kurady Laxminarayana
DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics
title DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics
title_full DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics
title_fullStr DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics
title_full_unstemmed DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics
title_short DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics
title_sort dna methylation and chromatin remodeling: the blueprint of cancer epigenetics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826949/
https://www.ncbi.nlm.nih.gov/pubmed/27119045
http://dx.doi.org/10.1155/2016/6072357
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