Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro

The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion....

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Detalles Bibliográficos
Autores principales: Patin, Emmanuel C, Willcocks, Sam, Orr, Selinda, Ward, Theresa H, Lang, Roland, Schaible, Ulrich E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826952/
https://www.ncbi.nlm.nih.gov/pubmed/26939595
http://dx.doi.org/10.1177/1753425916636671
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author Patin, Emmanuel C
Willcocks, Sam
Orr, Selinda
Ward, Theresa H
Lang, Roland
Schaible, Ulrich E
author_facet Patin, Emmanuel C
Willcocks, Sam
Orr, Selinda
Ward, Theresa H
Lang, Roland
Schaible, Ulrich E
author_sort Patin, Emmanuel C
collection PubMed
description The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.
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spelling pubmed-48269522016-04-21 Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro Patin, Emmanuel C Willcocks, Sam Orr, Selinda Ward, Theresa H Lang, Roland Schaible, Ulrich E Innate Immun Original Articles The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses. SAGE Publications 2016-03-02 2016-04 /pmc/articles/PMC4826952/ /pubmed/26939595 http://dx.doi.org/10.1177/1753425916636671 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Patin, Emmanuel C
Willcocks, Sam
Orr, Selinda
Ward, Theresa H
Lang, Roland
Schaible, Ulrich E
Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro
title Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro
title_full Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro
title_fullStr Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro
title_full_unstemmed Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro
title_short Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro
title_sort mincle-mediated anti-inflammatory il-10 response counter-regulates il-12 in vitro
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826952/
https://www.ncbi.nlm.nih.gov/pubmed/26939595
http://dx.doi.org/10.1177/1753425916636671
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