Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis

Hematopoietic stem cells (HSCs) form a rare population of multipotent stem cells, which give rise to all hematopoietic lineages. HSCs home to bone marrow niches and circulate between blood and bone marrow. Many factors, especially SDF1a, affect the circulation of HSCs, but these have not been fully...

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Detalles Bibliográficos
Autores principales: Asri, Amir, Sabour, Javid, Atashi, Amir, Soleimani, Masoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827072/
https://www.ncbi.nlm.nih.gov/pubmed/27092040
http://dx.doi.org/10.17179/excli2014-585
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author Asri, Amir
Sabour, Javid
Atashi, Amir
Soleimani, Masoud
author_facet Asri, Amir
Sabour, Javid
Atashi, Amir
Soleimani, Masoud
author_sort Asri, Amir
collection PubMed
description Hematopoietic stem cells (HSCs) form a rare population of multipotent stem cells, which give rise to all hematopoietic lineages. HSCs home to bone marrow niches and circulate between blood and bone marrow. Many factors, especially SDF1a, affect the circulation of HSCs, but these have not been fully recognized. SDF1a has been shown to bind CXCR7 in addition to CXCR4 and can also function as SDF1a/CXCR4 modulator. CXCR7 plays a role in HSCs homing via SDF1a gradient and is a mediator of CXCR4/SDF1a axis. This review describes the current concepts and questions concerning CXCR7/CXCR4/SDF1a axis as an important key in hematopoietic stem cells homing with particular emphasis on CXCR7 receptor. Homing of HSCs is an essential step for successful hematopoietic stem cell transplantation.
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spelling pubmed-48270722016-04-18 Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis Asri, Amir Sabour, Javid Atashi, Amir Soleimani, Masoud EXCLI J Review Article Hematopoietic stem cells (HSCs) form a rare population of multipotent stem cells, which give rise to all hematopoietic lineages. HSCs home to bone marrow niches and circulate between blood and bone marrow. Many factors, especially SDF1a, affect the circulation of HSCs, but these have not been fully recognized. SDF1a has been shown to bind CXCR7 in addition to CXCR4 and can also function as SDF1a/CXCR4 modulator. CXCR7 plays a role in HSCs homing via SDF1a gradient and is a mediator of CXCR4/SDF1a axis. This review describes the current concepts and questions concerning CXCR7/CXCR4/SDF1a axis as an important key in hematopoietic stem cells homing with particular emphasis on CXCR7 receptor. Homing of HSCs is an essential step for successful hematopoietic stem cell transplantation. Leibniz Research Centre for Working Environment and Human Factors 2016-02-15 /pmc/articles/PMC4827072/ /pubmed/27092040 http://dx.doi.org/10.17179/excli2014-585 Text en Copyright © 2016 Asri et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Review Article
Asri, Amir
Sabour, Javid
Atashi, Amir
Soleimani, Masoud
Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis
title Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis
title_full Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis
title_fullStr Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis
title_full_unstemmed Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis
title_short Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a/CXCR4 axis
title_sort homing in hematopoietic stem cells: focus on regulatory role of cxcr7 on sdf1a/cxcr4 axis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827072/
https://www.ncbi.nlm.nih.gov/pubmed/27092040
http://dx.doi.org/10.17179/excli2014-585
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