Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis

Mitochondria-targeted compounds are emerging as a new class of drugs that can potentially alter the pathophysiology of those diseases where mitochondrial dysfunction plays a critical role. We have synthesized a novel mitochondria-targeted esculetin (Mito-Esc) with an aim to investigate its effect du...

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Detalles Bibliográficos
Autores principales: Karnewar, Santosh, Vasamsetti, Sathish Babu, Gopoju, Raja, Kanugula, Anantha Koteswararao, Ganji, Sai Krishna, Prabhakar, Sripadi, Rangaraj, Nandini, Tupperwar, Nitin, Kumar, Jerald Mahesh, Kotamraju, Srigiridhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827087/
https://www.ncbi.nlm.nih.gov/pubmed/27063143
http://dx.doi.org/10.1038/srep24108

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