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Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells

MLN4924 is a recently discovered small molecule inhibitor of NEDD8-Activating Enzyme (NAE). Because cullin RING ligase (CRL), the largest family of E3 ubiquitin ligase, requires cullin neddylation for its activity, MLN4924, therefore, acts as an indirect inhibitor of CRL by blocking cullin neddylati...

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Detalles Bibliográficos
Autores principales:	Lan, Huiyin, Tang, Zaiming, Jin, Hongchuan, Sun, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827092/ https://www.ncbi.nlm.nih.gov/pubmed/27063292 http://dx.doi.org/10.1038/srep24218

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