An Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of Src Kinase

Phosphorylation of the activation loop is a fundamental step in the activation of most protein kinases. In the case of the Src tyrosine kinase, a prototypical kinase due to its role in cancer and its historic importance, phosphorylation of tyrosine 416 in the activation loop is known to rigidify the...

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Detalles Bibliográficos
Autores principales: Pucheta-Martínez, Encarna, Saladino, Giorgio, Morando, Maria Agnese, Martinez-Torrecuadrada, Jorge, Lelli, Moreno, Sutto, Ludovico, D’Amelio, Nicola, Gervasio, Francesco Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827121/
https://www.ncbi.nlm.nih.gov/pubmed/27063862
http://dx.doi.org/10.1038/srep24235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827121/
https://www.ncbi.nlm.nih.gov/pubmed/27063862
http://dx.doi.org/10.1038/srep24235

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