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A comparison of methods to adjust for continuous covariates in the analysis of randomised trials

BACKGROUND: Although covariate adjustment in the analysis of randomised trials can be beneficial, adjustment for continuous covariates is complicated by the fact that the association between covariate and outcome must be specified. Misspecification of this association can lead to reduced power, and...

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Detalles Bibliográficos
Autores principales: Kahan, Brennan C., Rushton, Helen, Morris, Tim P., Daniel, Rhian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827223/
https://www.ncbi.nlm.nih.gov/pubmed/27068456
http://dx.doi.org/10.1186/s12874-016-0141-3