FOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition

Cancer cells with stem cell properties (CSCs) underpin the chemotherapy resistance and high therapeutic failure of triple-negative breast cancers (TNBCs). Even though CSCs are known to proliferate more slowly, they are sensitive to inhibitors of G2/M kinases such as polo-like kinase 1 (PLK1). Unders...

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Detalles Bibliográficos
Autores principales: Pietilä, Mika, Vijay, Geraldine V., Soundararajan, Rama, Yu, Xian, Symmans, William F., Sphyris, Nathalie, Mani, Sendurai A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827390/
https://www.ncbi.nlm.nih.gov/pubmed/27064522
http://dx.doi.org/10.1038/srep23070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827390/
https://www.ncbi.nlm.nih.gov/pubmed/27064522
http://dx.doi.org/10.1038/srep23070

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