The Flagellum Attachment Zone: ‘The Cellular Ruler’ of Trypanosome Morphology

A defining feature of Trypanosoma brucei cell shape is the lateral attachment of the flagellum to the cell body, mediated by the flagellum attachment zone (FAZ). The FAZ is a complex cytoskeletal structure that connects the flagellum skeleton through two membranes to the cytoskeleton. The FAZ acts a...

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Detalles Bibliográficos
Autores principales: Sunter, Jack D., Gull, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827413/
https://www.ncbi.nlm.nih.gov/pubmed/26776656
http://dx.doi.org/10.1016/j.pt.2015.12.010
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author Sunter, Jack D.
Gull, Keith
author_facet Sunter, Jack D.
Gull, Keith
author_sort Sunter, Jack D.
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description A defining feature of Trypanosoma brucei cell shape is the lateral attachment of the flagellum to the cell body, mediated by the flagellum attachment zone (FAZ). The FAZ is a complex cytoskeletal structure that connects the flagellum skeleton through two membranes to the cytoskeleton. The FAZ acts as a ‘cellular ruler’ of morphology by regulating cell length and organelle position and is therefore critical for both cell division and life cycle differentiations. Here we provide an overview of the advances in our understanding of the composition, assembly, and function of the FAZ.
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spelling pubmed-48274132016-04-21 The Flagellum Attachment Zone: ‘The Cellular Ruler’ of Trypanosome Morphology Sunter, Jack D. Gull, Keith Trends Parasitol Review A defining feature of Trypanosoma brucei cell shape is the lateral attachment of the flagellum to the cell body, mediated by the flagellum attachment zone (FAZ). The FAZ is a complex cytoskeletal structure that connects the flagellum skeleton through two membranes to the cytoskeleton. The FAZ acts as a ‘cellular ruler’ of morphology by regulating cell length and organelle position and is therefore critical for both cell division and life cycle differentiations. Here we provide an overview of the advances in our understanding of the composition, assembly, and function of the FAZ. Elsevier Science 2016-04 /pmc/articles/PMC4827413/ /pubmed/26776656 http://dx.doi.org/10.1016/j.pt.2015.12.010 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sunter, Jack D.
Gull, Keith
The Flagellum Attachment Zone: ‘The Cellular Ruler’ of Trypanosome Morphology
title The Flagellum Attachment Zone: ‘The Cellular Ruler’ of Trypanosome Morphology
title_full The Flagellum Attachment Zone: ‘The Cellular Ruler’ of Trypanosome Morphology
title_fullStr The Flagellum Attachment Zone: ‘The Cellular Ruler’ of Trypanosome Morphology
title_full_unstemmed The Flagellum Attachment Zone: ‘The Cellular Ruler’ of Trypanosome Morphology
title_short The Flagellum Attachment Zone: ‘The Cellular Ruler’ of Trypanosome Morphology
title_sort flagellum attachment zone: ‘the cellular ruler’ of trypanosome morphology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827413/
https://www.ncbi.nlm.nih.gov/pubmed/26776656
http://dx.doi.org/10.1016/j.pt.2015.12.010
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