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Induced Foxp3(+) T Cells Colonizing Tolerated Allografts Exhibit the Hypomethylation Pattern Typical of Mature Regulatory T Cells

Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity, and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the gener...

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Detalles Bibliográficos
Autores principales:	Hilbrands, Robert, Chen, Ye, Kendal, Adrian R., Adams, Elizabeth, Cobbold, Stephen P., Waldmann, Herman, Howie, Duncan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827454/ https://www.ncbi.nlm.nih.gov/pubmed/27148253 http://dx.doi.org/10.3389/fimmu.2016.00124

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