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Mycobacterium tuberculosis infection in women with unexplained infertility
BACKGROUND: Genital tuberculosis (GTB) is an important cause of female infertility, especially in developing countries. The positive results of polymerase chain reaction (PCR) in endometrial GTB in the absence of tubal damage raise the possibility of the detection of sub-clinical or latent disease,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research and Clinical Center for Infertility
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827507/ https://www.ncbi.nlm.nih.gov/pubmed/27141534 |
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author | Eftekhar, Maryam Pourmasumi, Soheila Sabeti, Parvin Aflatoonian, Abbas Sheikhha, Mohammad Hasan |
author_facet | Eftekhar, Maryam Pourmasumi, Soheila Sabeti, Parvin Aflatoonian, Abbas Sheikhha, Mohammad Hasan |
author_sort | Eftekhar, Maryam |
collection | PubMed |
description | BACKGROUND: Genital tuberculosis (GTB) is an important cause of female infertility, especially in developing countries. The positive results of polymerase chain reaction (PCR) in endometrial GTB in the absence of tubal damage raise the possibility of the detection of sub-clinical or latent disease, with doubtful benefits of treatment. OBJECTIVE: To evaluate the mycobacterium tuberculosis infection in endometrial biopsy samples collected from unexplained infertile women attending Yazd Research and Clinical Center for Infertility by using PCR techniques. MATERIALS AND METHODS: In this cross sectional study, 144 infertile women with unexplained infertility aged 20-35 years old and normal Histro-saplango graphy findings were enrolled. Endometrial biopsy samples from each participant were tested for mycobacterium tuberculosis detecting by PCR. In 93 patients, peritoneal fluid was also taken for culture and PCR. RESULTS: The PCR results of endometrial specimens were negative in all cases, demonstrating that there was no GTB infection among our patients. CONCLUSION: Our results showed that GTB could not be considered as a major problem in women with unexplained infertility. Although, studies have indicated that PCR is a useful method in diagnosing early GTB disease in infertile women with no demonstrable evidence of tubal or endometrial involvement. |
format | Online Article Text |
id | pubmed-4827507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Research and Clinical Center for Infertility |
record_format | MEDLINE/PubMed |
spelling | pubmed-48275072016-05-02 Mycobacterium tuberculosis infection in women with unexplained infertility Eftekhar, Maryam Pourmasumi, Soheila Sabeti, Parvin Aflatoonian, Abbas Sheikhha, Mohammad Hasan Int J Reprod Biomed Original Article BACKGROUND: Genital tuberculosis (GTB) is an important cause of female infertility, especially in developing countries. The positive results of polymerase chain reaction (PCR) in endometrial GTB in the absence of tubal damage raise the possibility of the detection of sub-clinical or latent disease, with doubtful benefits of treatment. OBJECTIVE: To evaluate the mycobacterium tuberculosis infection in endometrial biopsy samples collected from unexplained infertile women attending Yazd Research and Clinical Center for Infertility by using PCR techniques. MATERIALS AND METHODS: In this cross sectional study, 144 infertile women with unexplained infertility aged 20-35 years old and normal Histro-saplango graphy findings were enrolled. Endometrial biopsy samples from each participant were tested for mycobacterium tuberculosis detecting by PCR. In 93 patients, peritoneal fluid was also taken for culture and PCR. RESULTS: The PCR results of endometrial specimens were negative in all cases, demonstrating that there was no GTB infection among our patients. CONCLUSION: Our results showed that GTB could not be considered as a major problem in women with unexplained infertility. Although, studies have indicated that PCR is a useful method in diagnosing early GTB disease in infertile women with no demonstrable evidence of tubal or endometrial involvement. Research and Clinical Center for Infertility 2015-12 /pmc/articles/PMC4827507/ /pubmed/27141534 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Eftekhar, Maryam Pourmasumi, Soheila Sabeti, Parvin Aflatoonian, Abbas Sheikhha, Mohammad Hasan Mycobacterium tuberculosis infection in women with unexplained infertility |
title | Mycobacterium tuberculosis infection in women with unexplained infertility |
title_full | Mycobacterium tuberculosis infection in women with unexplained infertility |
title_fullStr | Mycobacterium tuberculosis infection in women with unexplained infertility |
title_full_unstemmed | Mycobacterium tuberculosis infection in women with unexplained infertility |
title_short | Mycobacterium tuberculosis infection in women with unexplained infertility |
title_sort | mycobacterium tuberculosis infection in women with unexplained infertility |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827507/ https://www.ncbi.nlm.nih.gov/pubmed/27141534 |
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