Diagnostic Challenge of Desmoplastic Melanoma

Desmoplastic melanoma (DM) is a rare variant of spindle-cell malignant melanoma. DM is easily misdiagnosed at an early stage because it can be confused with benign entities. Histological analysis, including careful attention to the presence of atypical spindle cells, as well as to lymphocytic aggreg...

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Autores principales: Andreevscaia, Olga, Theate, Ivan, Goossens, Cathy, Vanhooteghem, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827642/
https://www.ncbi.nlm.nih.gov/pubmed/27134705
http://dx.doi.org/10.4081/rt.2016.5713
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author Andreevscaia, Olga
Theate, Ivan
Goossens, Cathy
Vanhooteghem, Olivier
author_facet Andreevscaia, Olga
Theate, Ivan
Goossens, Cathy
Vanhooteghem, Olivier
author_sort Andreevscaia, Olga
collection PubMed
description Desmoplastic melanoma (DM) is a rare variant of spindle-cell malignant melanoma. DM is easily misdiagnosed at an early stage because it can be confused with benign entities. Histological analysis, including careful attention to the presence of atypical spindle cells, as well as to lymphocytic aggregates in an abundant fibrotic stroma in the dermis, provides clues for diagnosis. The adjunction of an immunohistochemical panel, and particularly testing for S-100 protein, is needed for the final diagnosis.
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spelling pubmed-48276422016-04-29 Diagnostic Challenge of Desmoplastic Melanoma Andreevscaia, Olga Theate, Ivan Goossens, Cathy Vanhooteghem, Olivier Rare Tumors Case Report Desmoplastic melanoma (DM) is a rare variant of spindle-cell malignant melanoma. DM is easily misdiagnosed at an early stage because it can be confused with benign entities. Histological analysis, including careful attention to the presence of atypical spindle cells, as well as to lymphocytic aggregates in an abundant fibrotic stroma in the dermis, provides clues for diagnosis. The adjunction of an immunohistochemical panel, and particularly testing for S-100 protein, is needed for the final diagnosis. PAGEPress Publications, Pavia, Italy 2016-03-31 /pmc/articles/PMC4827642/ /pubmed/27134705 http://dx.doi.org/10.4081/rt.2016.5713 Text en ©Copyright O. Andreevscaia et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Andreevscaia, Olga
Theate, Ivan
Goossens, Cathy
Vanhooteghem, Olivier
Diagnostic Challenge of Desmoplastic Melanoma
title Diagnostic Challenge of Desmoplastic Melanoma
title_full Diagnostic Challenge of Desmoplastic Melanoma
title_fullStr Diagnostic Challenge of Desmoplastic Melanoma
title_full_unstemmed Diagnostic Challenge of Desmoplastic Melanoma
title_short Diagnostic Challenge of Desmoplastic Melanoma
title_sort diagnostic challenge of desmoplastic melanoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827642/
https://www.ncbi.nlm.nih.gov/pubmed/27134705
http://dx.doi.org/10.4081/rt.2016.5713
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