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Langerhan’s Cell Sarcoma: Two Case Reports

Langerhan’s cell sarcoma (LCS) is a rare neoplasm with a poor prognosis. To our knowledge, only sixty-six cases have been published. We discuss two patients who presented very differently with LCS, as well as a recently published review of all sixty-six cases. Our first case had a complicated histor...

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Autores principales: Kaleem, Tasneem A., Schild, Michael H., Miller, Daniel, Jha, Asit, Cortese, Cherise, Attia, Steven, Miller, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827650/
https://www.ncbi.nlm.nih.gov/pubmed/27134713
http://dx.doi.org/10.4081/rt.2016.6140
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author Kaleem, Tasneem A.
Schild, Michael H.
Miller, Daniel
Jha, Asit
Cortese, Cherise
Attia, Steven
Miller, Robert C.
author_facet Kaleem, Tasneem A.
Schild, Michael H.
Miller, Daniel
Jha, Asit
Cortese, Cherise
Attia, Steven
Miller, Robert C.
author_sort Kaleem, Tasneem A.
collection PubMed
description Langerhan’s cell sarcoma (LCS) is a rare neoplasm with a poor prognosis. To our knowledge, only sixty-six cases have been published. We discuss two patients who presented very differently with LCS, as well as a recently published review of all sixty-six cases. Our first case had a complicated history of metastatic, high-grade myxofibrosarcomas and presented with a single skin lesion of LCS which was treated with resection to a positive margin and adjuvant radiotherapy. The LCS recurred locoregionally and was again resected. The patient is alive two years after initial diagnosis. The second case presented with bone marrow and splenic involvement, leukocytosis, and thrombocytopenia. This patient had an excellent response to etoposide, prednisone, oncovorin, cyclophosphamide, and adriamycin, with normalization of the complete blood count, negative bone marrow biopsy at follow up, and splenectomy without viable neoplasm. This patient is alive without signs of disease at 16 months after initial diagnosis.
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spelling pubmed-48276502016-04-29 Langerhan’s Cell Sarcoma: Two Case Reports Kaleem, Tasneem A. Schild, Michael H. Miller, Daniel Jha, Asit Cortese, Cherise Attia, Steven Miller, Robert C. Rare Tumors Case Report Langerhan’s cell sarcoma (LCS) is a rare neoplasm with a poor prognosis. To our knowledge, only sixty-six cases have been published. We discuss two patients who presented very differently with LCS, as well as a recently published review of all sixty-six cases. Our first case had a complicated history of metastatic, high-grade myxofibrosarcomas and presented with a single skin lesion of LCS which was treated with resection to a positive margin and adjuvant radiotherapy. The LCS recurred locoregionally and was again resected. The patient is alive two years after initial diagnosis. The second case presented with bone marrow and splenic involvement, leukocytosis, and thrombocytopenia. This patient had an excellent response to etoposide, prednisone, oncovorin, cyclophosphamide, and adriamycin, with normalization of the complete blood count, negative bone marrow biopsy at follow up, and splenectomy without viable neoplasm. This patient is alive without signs of disease at 16 months after initial diagnosis. PAGEPress Publications, Pavia, Italy 2016-04-06 /pmc/articles/PMC4827650/ /pubmed/27134713 http://dx.doi.org/10.4081/rt.2016.6140 Text en ©Copyright T.A. Kaleem et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kaleem, Tasneem A.
Schild, Michael H.
Miller, Daniel
Jha, Asit
Cortese, Cherise
Attia, Steven
Miller, Robert C.
Langerhan’s Cell Sarcoma: Two Case Reports
title Langerhan’s Cell Sarcoma: Two Case Reports
title_full Langerhan’s Cell Sarcoma: Two Case Reports
title_fullStr Langerhan’s Cell Sarcoma: Two Case Reports
title_full_unstemmed Langerhan’s Cell Sarcoma: Two Case Reports
title_short Langerhan’s Cell Sarcoma: Two Case Reports
title_sort langerhan’s cell sarcoma: two case reports
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827650/
https://www.ncbi.nlm.nih.gov/pubmed/27134713
http://dx.doi.org/10.4081/rt.2016.6140
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