Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer

[Image: see text] For more than half a century the pharmaceutical industry has sifted through natural products produced by microbes, uncovering new scaffolds and fashioning them into a broad range of vital drugs. We sought a strategy to reinvigorate the discovery of natural products with distinctive...

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Detalles Bibliográficos
Autores principales: Goering, Anthony W., McClure, Ryan A., Doroghazi, James R., Albright, Jessica C., Haverland, Nicole A., Zhang, Yongbo, Ju, Kou-San, Thomson, Regan J., Metcalf, William W., Kelleher, Neil L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827660/
https://www.ncbi.nlm.nih.gov/pubmed/27163034
http://dx.doi.org/10.1021/acscentsci.5b00331

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