Does amantadine induce acute psychosis? A case report and literature review

BACKGROUND: Over-the-counter cold medicines, which contain amantadine, are widely used in the People’s Republic of China. Clinicians are familiar with the psychosis caused by long-term treatment with amantadine, especially in elderly patients; however, early-onset psychotic complications among healt...

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Detalles Bibliográficos
Autores principales: Xu, Wei-juan, Wei, Ning, Xu, Yi, Hu, Shao-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827899/
https://www.ncbi.nlm.nih.gov/pubmed/27103808
http://dx.doi.org/10.2147/NDT.S101569
Descripción
Sumario:BACKGROUND: Over-the-counter cold medicines, which contain amantadine, are widely used in the People’s Republic of China. Clinicians are familiar with the psychosis caused by long-term treatment with amantadine, especially in elderly patients; however, early-onset psychotic complications among healthy young individuals have rarely been reported. CASE PRESENTATION: This article reports the case of a 28-year-old patient who presented with hallucination–delusion syndrome soon after treatment with cold medicine containing amantadine hydrochloride and acetaminophen. The symptoms resolved completely after a 2-week course of paliperidone treatment. CONCLUSION: Clinicians should be sensitive to the acute psychotic complications induced by an interaction between amantadine and acetaminophen.

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