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Associations between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer: a meta-analysis of 39,736 subjects
BACKGROUND: Previous studies have investigated the associations between the common polymorphisms in FAS/FASL genes and lung cancer risk; however, the results remain inconsistent and inconclusive. Hence, we performed a meta-analysis to reassess the relationships between FAS rs2234767 and FASL rs76311...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827906/ https://www.ncbi.nlm.nih.gov/pubmed/27103831 http://dx.doi.org/10.2147/OTT.S102723 |
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author | Yu, Xiongjie Li, Yanli Yu, Yuandong Lei, Jinhua Wan, Guoxing Cao, Fengjun |
author_facet | Yu, Xiongjie Li, Yanli Yu, Yuandong Lei, Jinhua Wan, Guoxing Cao, Fengjun |
author_sort | Yu, Xiongjie |
collection | PubMed |
description | BACKGROUND: Previous studies have investigated the associations between the common polymorphisms in FAS/FASL genes and lung cancer risk; however, the results remain inconsistent and inconclusive. Hence, we performed a meta-analysis to reassess the relationships between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer. METHODS: Eligible studies retrieved by an electronic search were pooled to calculate the strength of the associations using the odds ratio (OR) and 95% confidence interval (95% CI). RESULTS: A total of 13 case–control studies involving 39,736 subjects (9,237 cases and 10,838 controls on FAS rs2234767 and 8,957 cases and 10,704 controls on FASL rs763110) were included in the meta-analysis. The results showed a significant association between FAS rs2234767 polymorphism and increased risk of lung cancer (A vs G: OR =1.07, 95% CI =1.01–1.13; AA vs GG: OR =1.23, 95% CI =1.06–1.43; AA vs GA + GG: OR =1.24, 95% CI =1.08–1.43). Similar association was also observed in Asian population (AA vs GA + GG: OR =1.30, 95% CI =1.01–1.67) and in the studies with large sample size (A vs G: OR =1.07, 95% CI =1.00–1.14; AA vs GG: OR =1.30, 95% CI =1.07–1.58). However, no significant association between FASL rs763110 polymorphism and lung cancer risk was found other than in the Asian population (CC vs TC + TT: OR =1.35, 95% CI =1.01–1.80). CONCLUSION: The meta-analysis indicated that FAS rs2234767 polymorphism was significantly associated with an increased risk of lung cancer and FASL rs763110 polymorphism may not contribute to susceptibility to lung cancer other than in Asian population. |
format | Online Article Text |
id | pubmed-4827906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48279062016-04-21 Associations between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer: a meta-analysis of 39,736 subjects Yu, Xiongjie Li, Yanli Yu, Yuandong Lei, Jinhua Wan, Guoxing Cao, Fengjun Onco Targets Ther Original Research BACKGROUND: Previous studies have investigated the associations between the common polymorphisms in FAS/FASL genes and lung cancer risk; however, the results remain inconsistent and inconclusive. Hence, we performed a meta-analysis to reassess the relationships between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer. METHODS: Eligible studies retrieved by an electronic search were pooled to calculate the strength of the associations using the odds ratio (OR) and 95% confidence interval (95% CI). RESULTS: A total of 13 case–control studies involving 39,736 subjects (9,237 cases and 10,838 controls on FAS rs2234767 and 8,957 cases and 10,704 controls on FASL rs763110) were included in the meta-analysis. The results showed a significant association between FAS rs2234767 polymorphism and increased risk of lung cancer (A vs G: OR =1.07, 95% CI =1.01–1.13; AA vs GG: OR =1.23, 95% CI =1.06–1.43; AA vs GA + GG: OR =1.24, 95% CI =1.08–1.43). Similar association was also observed in Asian population (AA vs GA + GG: OR =1.30, 95% CI =1.01–1.67) and in the studies with large sample size (A vs G: OR =1.07, 95% CI =1.00–1.14; AA vs GG: OR =1.30, 95% CI =1.07–1.58). However, no significant association between FASL rs763110 polymorphism and lung cancer risk was found other than in the Asian population (CC vs TC + TT: OR =1.35, 95% CI =1.01–1.80). CONCLUSION: The meta-analysis indicated that FAS rs2234767 polymorphism was significantly associated with an increased risk of lung cancer and FASL rs763110 polymorphism may not contribute to susceptibility to lung cancer other than in Asian population. Dove Medical Press 2016-04-06 /pmc/articles/PMC4827906/ /pubmed/27103831 http://dx.doi.org/10.2147/OTT.S102723 Text en © 2016 Yu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Yu, Xiongjie Li, Yanli Yu, Yuandong Lei, Jinhua Wan, Guoxing Cao, Fengjun Associations between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer: a meta-analysis of 39,736 subjects |
title | Associations between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer: a meta-analysis of 39,736 subjects |
title_full | Associations between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer: a meta-analysis of 39,736 subjects |
title_fullStr | Associations between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer: a meta-analysis of 39,736 subjects |
title_full_unstemmed | Associations between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer: a meta-analysis of 39,736 subjects |
title_short | Associations between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer: a meta-analysis of 39,736 subjects |
title_sort | associations between fas rs2234767 and fasl rs763110 polymorphisms and the risk of lung cancer: a meta-analysis of 39,736 subjects |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827906/ https://www.ncbi.nlm.nih.gov/pubmed/27103831 http://dx.doi.org/10.2147/OTT.S102723 |
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