Cargando…

Low-grade inflammation predicts persistence of depressive symptoms

RATIONALE: Evidence suggests that depression is cross-sectionally and longitudinally associated with activation of inflammatory response system. A few studies, however, have investigated the longitudinal relationship between raised inflammatory biomarkers and persistence of depressive symptoms. We e...

Descripción completa

Detalles Bibliográficos
Autores principales: Zalli, A., Jovanova, O., Hoogendijk, W. J. G., Tiemeier, H., Carvalho, L. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828485/
https://www.ncbi.nlm.nih.gov/pubmed/25877654
http://dx.doi.org/10.1007/s00213-015-3919-9
_version_ 1782426586512883712
author Zalli, A.
Jovanova, O.
Hoogendijk, W. J. G.
Tiemeier, H.
Carvalho, L. A.
author_facet Zalli, A.
Jovanova, O.
Hoogendijk, W. J. G.
Tiemeier, H.
Carvalho, L. A.
author_sort Zalli, A.
collection PubMed
description RATIONALE: Evidence suggests that depression is cross-sectionally and longitudinally associated with activation of inflammatory response system. A few studies, however, have investigated the longitudinal relationship between raised inflammatory biomarkers and persistence of depressive symptoms. We examined the temporal relationship between serum levels of inflammatory biomarkers and persistence of depressive symptoms among older participants. METHODS: Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess depressive symptoms at baseline and at 5-year follow-up in 656 participants (233 men, 423 women) aged >60 years of the Rotterdam Study. Markers of inflammation interleukin (IL)-6, alpha-1-antichymotrypsin (ACT) and C-reactive protein (CRP) were assessed at baseline, and all participants taking antidepressant medications were excluded from the analysis. RESULTS: No cross-sectional association was found between IL-6, ACT and CRP with depressive symptoms at baseline. However, higher levels of IL-6 and CRP predicted depressive symptoms at 5-year follow-up. Adjustment for confounding variables had no impact on the observed associations. Similarly, a positive association was found between baseline levels of IL-6 (OR = 2.44, p = 0.030) and CRP (OR = 1.81, p = 0.052) and persistence of depressive symptoms over 5 years. CONCLUSION: Our data suggest that dysregulation of the inflammatory response system is associated with a more severe form of depression more likely to re-occur.
format Online
Article
Text
id pubmed-4828485
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-48284852016-04-21 Low-grade inflammation predicts persistence of depressive symptoms Zalli, A. Jovanova, O. Hoogendijk, W. J. G. Tiemeier, H. Carvalho, L. A. Psychopharmacology (Berl) Original Investigation RATIONALE: Evidence suggests that depression is cross-sectionally and longitudinally associated with activation of inflammatory response system. A few studies, however, have investigated the longitudinal relationship between raised inflammatory biomarkers and persistence of depressive symptoms. We examined the temporal relationship between serum levels of inflammatory biomarkers and persistence of depressive symptoms among older participants. METHODS: Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess depressive symptoms at baseline and at 5-year follow-up in 656 participants (233 men, 423 women) aged >60 years of the Rotterdam Study. Markers of inflammation interleukin (IL)-6, alpha-1-antichymotrypsin (ACT) and C-reactive protein (CRP) were assessed at baseline, and all participants taking antidepressant medications were excluded from the analysis. RESULTS: No cross-sectional association was found between IL-6, ACT and CRP with depressive symptoms at baseline. However, higher levels of IL-6 and CRP predicted depressive symptoms at 5-year follow-up. Adjustment for confounding variables had no impact on the observed associations. Similarly, a positive association was found between baseline levels of IL-6 (OR = 2.44, p = 0.030) and CRP (OR = 1.81, p = 0.052) and persistence of depressive symptoms over 5 years. CONCLUSION: Our data suggest that dysregulation of the inflammatory response system is associated with a more severe form of depression more likely to re-occur. Springer Berlin Heidelberg 2015-04-16 2016 /pmc/articles/PMC4828485/ /pubmed/25877654 http://dx.doi.org/10.1007/s00213-015-3919-9 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Investigation
Zalli, A.
Jovanova, O.
Hoogendijk, W. J. G.
Tiemeier, H.
Carvalho, L. A.
Low-grade inflammation predicts persistence of depressive symptoms
title Low-grade inflammation predicts persistence of depressive symptoms
title_full Low-grade inflammation predicts persistence of depressive symptoms
title_fullStr Low-grade inflammation predicts persistence of depressive symptoms
title_full_unstemmed Low-grade inflammation predicts persistence of depressive symptoms
title_short Low-grade inflammation predicts persistence of depressive symptoms
title_sort low-grade inflammation predicts persistence of depressive symptoms
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828485/
https://www.ncbi.nlm.nih.gov/pubmed/25877654
http://dx.doi.org/10.1007/s00213-015-3919-9
work_keys_str_mv AT zallia lowgradeinflammationpredictspersistenceofdepressivesymptoms
AT jovanovao lowgradeinflammationpredictspersistenceofdepressivesymptoms
AT hoogendijkwjg lowgradeinflammationpredictspersistenceofdepressivesymptoms
AT tiemeierh lowgradeinflammationpredictspersistenceofdepressivesymptoms
AT carvalhola lowgradeinflammationpredictspersistenceofdepressivesymptoms