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NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1

ABSTRACT: Benzo[a]pyrene (BaP) is a human carcinogen that covalently binds to DNA after metabolic activation by cytochrome P450 (CYP) enzymes. Here we investigated the efficiencies of rat hepatic microsomes and rat recombinant CYP1A1 expressed with its reductase, NADPH:CYP oxidoreductase (POR), NADH...

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Detalles Bibliográficos
Autores principales:	Stiborová, Marie, Indra, Radek, Moserová, Michaela, Šulc, Miroslav, Hodek, Petr, Frei, Eva, Schmeiser, Heinz H., Arlt, Volker M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Vienna 2016
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828493/ https://www.ncbi.nlm.nih.gov/pubmed/27110038 http://dx.doi.org/10.1007/s00706-016-1713-y

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