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Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events

Some degree of external root resorption is a frequent, unpredictable, and unavoidable consequence of orthodontic tooth movement mediated by odontoclasts/cementoclasts originating from circulating precursor cells in the periodontal ligament. Its pathogenesis involves mechanical forces initiating comp...

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Detalles Bibliográficos
Autores principales: Feller, Liviu, Khammissa, Razia A. G., Thomadakis, George, Fourie, Jeanine, Lemmer, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828521/
https://www.ncbi.nlm.nih.gov/pubmed/27119080
http://dx.doi.org/10.1155/2016/4864195
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author Feller, Liviu
Khammissa, Razia A. G.
Thomadakis, George
Fourie, Jeanine
Lemmer, Johan
author_facet Feller, Liviu
Khammissa, Razia A. G.
Thomadakis, George
Fourie, Jeanine
Lemmer, Johan
author_sort Feller, Liviu
collection PubMed
description Some degree of external root resorption is a frequent, unpredictable, and unavoidable consequence of orthodontic tooth movement mediated by odontoclasts/cementoclasts originating from circulating precursor cells in the periodontal ligament. Its pathogenesis involves mechanical forces initiating complex interactions between signalling pathways activated by various biological agents. Resorption of cementum is regulated by mechanisms similar to those controlling osteoclastogenesis and bone resorption. Following root resorption there is repair by cellular cementum, but factors mediating the transition from resorption to repair are not clear. In this paper we review some of the biological events associated with orthodontically induced external root resorption.
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spelling pubmed-48285212016-04-26 Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events Feller, Liviu Khammissa, Razia A. G. Thomadakis, George Fourie, Jeanine Lemmer, Johan Biomed Res Int Review Article Some degree of external root resorption is a frequent, unpredictable, and unavoidable consequence of orthodontic tooth movement mediated by odontoclasts/cementoclasts originating from circulating precursor cells in the periodontal ligament. Its pathogenesis involves mechanical forces initiating complex interactions between signalling pathways activated by various biological agents. Resorption of cementum is regulated by mechanisms similar to those controlling osteoclastogenesis and bone resorption. Following root resorption there is repair by cellular cementum, but factors mediating the transition from resorption to repair are not clear. In this paper we review some of the biological events associated with orthodontically induced external root resorption. Hindawi Publishing Corporation 2016 2016-03-29 /pmc/articles/PMC4828521/ /pubmed/27119080 http://dx.doi.org/10.1155/2016/4864195 Text en Copyright © 2016 Liviu Feller et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Feller, Liviu
Khammissa, Razia A. G.
Thomadakis, George
Fourie, Jeanine
Lemmer, Johan
Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events
title Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events
title_full Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events
title_fullStr Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events
title_full_unstemmed Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events
title_short Apical External Root Resorption and Repair in Orthodontic Tooth Movement: Biological Events
title_sort apical external root resorption and repair in orthodontic tooth movement: biological events
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828521/
https://www.ncbi.nlm.nih.gov/pubmed/27119080
http://dx.doi.org/10.1155/2016/4864195
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