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Regional MRI Diffusion, White-Matter Hyperintensities, and Cognitive Function in Alzheimer's Disease and Vascular Dementia
BACKGROUND AND PURPOSE: An increase in brain water diffusivity as measured using magnetic resonance imaging (MRI) has been recently reported in normal-appearing white matter (NAWM) in patients affected by cognitive impairment. However, it remains to be clarified if this reflects an overt neuronal ti...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neurological Association
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828567/ https://www.ncbi.nlm.nih.gov/pubmed/27074295 http://dx.doi.org/10.3988/jcn.2016.12.2.201 |
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author | Altamura, Claudia Scrascia, Federica Quattrocchi, Carlo Cosimo Errante, Yuri Gangemi, Emma Curcio, Giuseppe Ursini, Francesca Silvestrini, Mauro Maggio, Paola Beomonte Zobel, Bruno Rossini, Paolo Maria Pasqualetti, Patrizio Falsetti, Lorenzo Vernieri, Fabrizio |
author_facet | Altamura, Claudia Scrascia, Federica Quattrocchi, Carlo Cosimo Errante, Yuri Gangemi, Emma Curcio, Giuseppe Ursini, Francesca Silvestrini, Mauro Maggio, Paola Beomonte Zobel, Bruno Rossini, Paolo Maria Pasqualetti, Patrizio Falsetti, Lorenzo Vernieri, Fabrizio |
author_sort | Altamura, Claudia |
collection | PubMed |
description | BACKGROUND AND PURPOSE: An increase in brain water diffusivity as measured using magnetic resonance imaging (MRI) has been recently reported in normal-appearing white matter (NAWM) in patients affected by cognitive impairment. However, it remains to be clarified if this reflects an overt neuronal tissue disruption that leads to degenerative or microvascular lesions. This question was addressed by comparing the regional MRI apparent diffusion coefficients (ADCs) of NAWM in patients affected by Alzheimer's disease (AD) or vascular dementia (VaD). The relationships of ADCs with the white-matter hyperintensity (WMH) burden, carotid atherosclerosis, and cognitive performance were also investigated. METHODS: Forty-nine AD and 31 VaD patients underwent brain MRI to assess the WMH volume and regional NAWM ADCs, neuropsychological evaluations, and carotid ultrasound to assess the plaque severity and intima-media thickness (IMT). RESULTS: Regional ADCs in NAWM did not differ between VaD and AD patients, while the WMH volume was greater in VaD than in AD patients. The ADC in the anterior corpus callosum was related to the WMH volume, while a greater carotid IMT was positively correlated with the temporal ADC and WMH volume. The memory performance was worse in patients with higher temporal ADCs. Constructional praxis scores were related to ADCs in the frontal, and occipital lobes, in the anterior and posterior corpus callosum as well as to the WMH volume. Abstract reasoning was related to frontal, parietal, and temporal ADCs. CONCLUSIONS: Our data show that higher regional ADCs in NAWM are associated with microcirculatory impairment, as depicted by the WMH volume. Moreover, regional ADCs in NAWM are differently associated with the neuropsychological performances in memory, constructional praxia, and abstract reasoning domains. |
format | Online Article Text |
id | pubmed-4828567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean Neurological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-48285672016-04-21 Regional MRI Diffusion, White-Matter Hyperintensities, and Cognitive Function in Alzheimer's Disease and Vascular Dementia Altamura, Claudia Scrascia, Federica Quattrocchi, Carlo Cosimo Errante, Yuri Gangemi, Emma Curcio, Giuseppe Ursini, Francesca Silvestrini, Mauro Maggio, Paola Beomonte Zobel, Bruno Rossini, Paolo Maria Pasqualetti, Patrizio Falsetti, Lorenzo Vernieri, Fabrizio J Clin Neurol Original Article BACKGROUND AND PURPOSE: An increase in brain water diffusivity as measured using magnetic resonance imaging (MRI) has been recently reported in normal-appearing white matter (NAWM) in patients affected by cognitive impairment. However, it remains to be clarified if this reflects an overt neuronal tissue disruption that leads to degenerative or microvascular lesions. This question was addressed by comparing the regional MRI apparent diffusion coefficients (ADCs) of NAWM in patients affected by Alzheimer's disease (AD) or vascular dementia (VaD). The relationships of ADCs with the white-matter hyperintensity (WMH) burden, carotid atherosclerosis, and cognitive performance were also investigated. METHODS: Forty-nine AD and 31 VaD patients underwent brain MRI to assess the WMH volume and regional NAWM ADCs, neuropsychological evaluations, and carotid ultrasound to assess the plaque severity and intima-media thickness (IMT). RESULTS: Regional ADCs in NAWM did not differ between VaD and AD patients, while the WMH volume was greater in VaD than in AD patients. The ADC in the anterior corpus callosum was related to the WMH volume, while a greater carotid IMT was positively correlated with the temporal ADC and WMH volume. The memory performance was worse in patients with higher temporal ADCs. Constructional praxis scores were related to ADCs in the frontal, and occipital lobes, in the anterior and posterior corpus callosum as well as to the WMH volume. Abstract reasoning was related to frontal, parietal, and temporal ADCs. CONCLUSIONS: Our data show that higher regional ADCs in NAWM are associated with microcirculatory impairment, as depicted by the WMH volume. Moreover, regional ADCs in NAWM are differently associated with the neuropsychological performances in memory, constructional praxia, and abstract reasoning domains. Korean Neurological Association 2016-04 2016-03-31 /pmc/articles/PMC4828567/ /pubmed/27074295 http://dx.doi.org/10.3988/jcn.2016.12.2.201 Text en Copyright © 2016 Korean Neurological Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Altamura, Claudia Scrascia, Federica Quattrocchi, Carlo Cosimo Errante, Yuri Gangemi, Emma Curcio, Giuseppe Ursini, Francesca Silvestrini, Mauro Maggio, Paola Beomonte Zobel, Bruno Rossini, Paolo Maria Pasqualetti, Patrizio Falsetti, Lorenzo Vernieri, Fabrizio Regional MRI Diffusion, White-Matter Hyperintensities, and Cognitive Function in Alzheimer's Disease and Vascular Dementia |
title | Regional MRI Diffusion, White-Matter Hyperintensities, and Cognitive Function in Alzheimer's Disease and Vascular Dementia |
title_full | Regional MRI Diffusion, White-Matter Hyperintensities, and Cognitive Function in Alzheimer's Disease and Vascular Dementia |
title_fullStr | Regional MRI Diffusion, White-Matter Hyperintensities, and Cognitive Function in Alzheimer's Disease and Vascular Dementia |
title_full_unstemmed | Regional MRI Diffusion, White-Matter Hyperintensities, and Cognitive Function in Alzheimer's Disease and Vascular Dementia |
title_short | Regional MRI Diffusion, White-Matter Hyperintensities, and Cognitive Function in Alzheimer's Disease and Vascular Dementia |
title_sort | regional mri diffusion, white-matter hyperintensities, and cognitive function in alzheimer's disease and vascular dementia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828567/ https://www.ncbi.nlm.nih.gov/pubmed/27074295 http://dx.doi.org/10.3988/jcn.2016.12.2.201 |
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