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Cardiovagal Baroreflex Sensitivity in Parkinson's Disease and Multiple-System Atrophy

BACKGROUND AND PURPOSE: Parkinson's disease (PD) and multiple-system atrophy of the parkinsonian type (MSA-P) are progressive neurodegenerative disorders that in addition to dysfunction of the motor system also present with features of dysautonomia, frequently manifesting as orthostatic hypoten...

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Autores principales: Roy, Sankanika, Jaryal, Ashok Kumar, Srivastava, Achal Kumar, Deepak, Kishore Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurological Association 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828569/
https://www.ncbi.nlm.nih.gov/pubmed/26869371
http://dx.doi.org/10.3988/jcn.2016.12.2.218
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author Roy, Sankanika
Jaryal, Ashok Kumar
Srivastava, Achal Kumar
Deepak, Kishore Kumar
author_facet Roy, Sankanika
Jaryal, Ashok Kumar
Srivastava, Achal Kumar
Deepak, Kishore Kumar
author_sort Roy, Sankanika
collection PubMed
description BACKGROUND AND PURPOSE: Parkinson's disease (PD) and multiple-system atrophy of the parkinsonian type (MSA-P) are progressive neurodegenerative disorders that in addition to dysfunction of the motor system also present with features of dysautonomia, frequently manifesting as orthostatic hypotension (OH). The pathophysiology of OH has been proposed to differ between these two disorders. This study investigated the spontaneous and cardiovagal baroreflex sensitivity (BRS) in Parkinson's disease patients with orthostatic hypotension (PD(OH)) and multiple system atrophy of Parkinsonian type with orthostatic hypotension in an attempt to differentiate the two disorders. METHODS: Two methods were used for determining the BRS: a spontaneous method (spontaneous BRS) and the reflexive baroreflex gain (cardiovagal BRS) from phases II and IV of the Valsalva maneuver (VM) in PD(OH) and MSA-P(OH). RESULTS: The spontaneous BRS (5.04±0.66 ms/mm Hg vs. 4.78±0.64 ms/mm Hg, p=0.54) and the cardiovagal BRS from phase II of the VM (0.96±0.75 ms/mm Hg vs. 1.34±1.51 ms/mm Hg, p=0.76) did not differ between PD(OH) and MSA-P(OH), but the cardiovagal BRS from phase IV of the VM (0.03±0.07 ms/mm Hg vs. 2.86±2.39 ms/mm Hg, p=0.004) was significantly lower in PD(OH). CONCLUSIONS: The cardiovagal BRS from phase IV of the VM has potential for differentiating PD(OH) and MSA-P(OH), indicating a difference in the pathophysiological mechanisms underlying the autonomic dysfunction in the two disorders.
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spelling pubmed-48285692016-04-21 Cardiovagal Baroreflex Sensitivity in Parkinson's Disease and Multiple-System Atrophy Roy, Sankanika Jaryal, Ashok Kumar Srivastava, Achal Kumar Deepak, Kishore Kumar J Clin Neurol Original Article BACKGROUND AND PURPOSE: Parkinson's disease (PD) and multiple-system atrophy of the parkinsonian type (MSA-P) are progressive neurodegenerative disorders that in addition to dysfunction of the motor system also present with features of dysautonomia, frequently manifesting as orthostatic hypotension (OH). The pathophysiology of OH has been proposed to differ between these two disorders. This study investigated the spontaneous and cardiovagal baroreflex sensitivity (BRS) in Parkinson's disease patients with orthostatic hypotension (PD(OH)) and multiple system atrophy of Parkinsonian type with orthostatic hypotension in an attempt to differentiate the two disorders. METHODS: Two methods were used for determining the BRS: a spontaneous method (spontaneous BRS) and the reflexive baroreflex gain (cardiovagal BRS) from phases II and IV of the Valsalva maneuver (VM) in PD(OH) and MSA-P(OH). RESULTS: The spontaneous BRS (5.04±0.66 ms/mm Hg vs. 4.78±0.64 ms/mm Hg, p=0.54) and the cardiovagal BRS from phase II of the VM (0.96±0.75 ms/mm Hg vs. 1.34±1.51 ms/mm Hg, p=0.76) did not differ between PD(OH) and MSA-P(OH), but the cardiovagal BRS from phase IV of the VM (0.03±0.07 ms/mm Hg vs. 2.86±2.39 ms/mm Hg, p=0.004) was significantly lower in PD(OH). CONCLUSIONS: The cardiovagal BRS from phase IV of the VM has potential for differentiating PD(OH) and MSA-P(OH), indicating a difference in the pathophysiological mechanisms underlying the autonomic dysfunction in the two disorders. Korean Neurological Association 2016-04 2016-02-04 /pmc/articles/PMC4828569/ /pubmed/26869371 http://dx.doi.org/10.3988/jcn.2016.12.2.218 Text en Copyright © 2016 Korean Neurological Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Roy, Sankanika
Jaryal, Ashok Kumar
Srivastava, Achal Kumar
Deepak, Kishore Kumar
Cardiovagal Baroreflex Sensitivity in Parkinson's Disease and Multiple-System Atrophy
title Cardiovagal Baroreflex Sensitivity in Parkinson's Disease and Multiple-System Atrophy
title_full Cardiovagal Baroreflex Sensitivity in Parkinson's Disease and Multiple-System Atrophy
title_fullStr Cardiovagal Baroreflex Sensitivity in Parkinson's Disease and Multiple-System Atrophy
title_full_unstemmed Cardiovagal Baroreflex Sensitivity in Parkinson's Disease and Multiple-System Atrophy
title_short Cardiovagal Baroreflex Sensitivity in Parkinson's Disease and Multiple-System Atrophy
title_sort cardiovagal baroreflex sensitivity in parkinson's disease and multiple-system atrophy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828569/
https://www.ncbi.nlm.nih.gov/pubmed/26869371
http://dx.doi.org/10.3988/jcn.2016.12.2.218
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