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Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase

[Image: see text] AR-12/OSU-03012 is an antitumor celecoxib-derivative that has progressed to Phase I clinical trial as an anticancer agent and has activity against a number of infectious agents including fungi, bacteria and viruses. However, the mechanism of these activities has remained unclear. B...

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Detalles Bibliográficos
Autores principales:	Koselny, Kristy, Green, Julianne, Favazzo, Lacey, Glazier, Virginia E., DiDone, Louis, Ransford, Shea, Krysan, Damian J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828684/ https://www.ncbi.nlm.nih.gov/pubmed/27088128 http://dx.doi.org/10.1021/acsinfecdis.5b00134

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