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Kindlin-2 directly binds actin and regulates integrin outside-in signaling
Reduced levels of kindlin-2 (K2) in endothelial cells derived from K2(+/−) mice or C2C12 myoblastoid cells treated with K2 siRNA showed disorganization of their actin cytoskeleton and decreased spreading. These marked changes led us to examine direct binding between K2 and actin. Purified K2 interac...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828686/ https://www.ncbi.nlm.nih.gov/pubmed/27044892 http://dx.doi.org/10.1083/jcb.201501006 |