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Sigma1 receptors inhibit store-operated Ca(2+) entry by attenuating coupling of STIM1 to Orai1

Sigma1 receptors (σ1Rs) are expressed widely; they bind diverse ligands, including psychotropic drugs and steroids, regulate many ion channels, and are implicated in cancer and addiction. It is not known how σ1Rs exert such varied effects. We demonstrate that σ1Rs inhibit store-operated Ca(2+) entry...

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Detalles Bibliográficos
Autores principales:	Srivats, Shyam, Balasuriya, Dilshan, Pasche, Mathias, Vistal, Gerard, Edwardson, J. Michael, Taylor, Colin W., Murrell-Lagnado, Ruth D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828687/ https://www.ncbi.nlm.nih.gov/pubmed/27069021 http://dx.doi.org/10.1083/jcb.201506022

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