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Treatment with anti-IL-6 receptor antibody prevented increase in serum hepcidin levels and improved anemia in mice inoculated with IL-6–producing lung carcinoma cells

BACKGROUND: Hepcidin, a key regulator of iron metabolism, is produced mainly by interleukin-6 (IL-6) during inflammation. A mechanism linking cancer-related anemia and IL-6 through hepcidin production is suggested. To clarify the hypothesis that overproduction of IL-6 elevates hepcidin levels and co...

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Detalles Bibliográficos
Autores principales:	Noguchi-Sasaki, Mariko, Sasaki, Yusuke, Shimonaka, Yasushi, Mori, Kazushige, Fujimoto-Ouchi, Kaori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828826/ https://www.ncbi.nlm.nih.gov/pubmed/27068103 http://dx.doi.org/10.1186/s12885-016-2305-2

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