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Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress
Accumulating evidence indicates that angiotensin-converting enzyme 2 (ACE2) plays a critical role in cardiovascular homeostasis, and its altered expression is associated with major cardiac and vascular disorders. The aim of this study was to evaluate the regulation of vascular function and assess th...
Autores principales: | Rabelo, Luiza A., Todiras, Mihail, Nunes-Souza, Valéria, Qadri, Fatimunnisa, Szijártó, István András, Gollasch, Maik, Penninger, Josef M., Bader, Michael, Santos, Robson A., Alenina, Natalia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829150/ https://www.ncbi.nlm.nih.gov/pubmed/27070147 http://dx.doi.org/10.1371/journal.pone.0150255 |
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