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Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction

Alzheimer’s disease (AD) researchers have struggled for decades to draw a causal link between extracellular Aβ aggregation and intraneuronal accumulation of microtubule-associated protein tau. The amyloid cascade hypothesis posits that Aβ deposition promotes tau hyperphosphorylation, tangle formatio...

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Detalles Bibliográficos
Autores principales:	Yetman, Michael J., Fowler, Stephanie W., Jankowsky, Joanna L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829202/ https://www.ncbi.nlm.nih.gov/pubmed/27070146 http://dx.doi.org/10.1371/journal.pone.0153724

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