Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

BACKGROUND: The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione...

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Detalles Bibliográficos
Autores principales: Benítez, Diego, Medeiros, Andrea, Fiestas, Lucía, Panozzo-Zenere, Esteban A., Maiwald, Franziska, Prousis, Kyriakos C., Roussaki, Marina, Calogeropoulou, Theodora, Detsi, Anastasia, Jaeger, Timo, Šarlauskas, Jonas, Peterlin Mašič, Lucíja, Kunick, Conrad, Labadie, Guillermo R., Flohé, Leopold, Comini, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829233/
https://www.ncbi.nlm.nih.gov/pubmed/27070550
http://dx.doi.org/10.1371/journal.pntd.0004617

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