The Translocation Domain of Botulinum Neurotoxin A Moderates the Propensity of the Catalytic Domain to Interact with Membranes at Acidic pH

Botulinum neurotoxin A (BoNT/A) is composed of three domains: a catalytic domain (LC), a translocation domain (H(N)) and a receptor-binding domain (H(C)). Like most bacterial toxins BoNT/A is an amphitropic protein, produced in a soluble form that is able to interact, penetrate and/or cross a membra...

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Detalles Bibliográficos
Autores principales: Araye, Anne, Goudet, Amélie, Barbier, Julien, Pichard, Sylvain, Baron, Bruno, England, Patrick, Pérez, Javier, Zinn-Justin, Sophie, Chenal, Alexandre, Gillet, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829238/
https://www.ncbi.nlm.nih.gov/pubmed/27070312
http://dx.doi.org/10.1371/journal.pone.0153401

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