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Dispositions of enrofloxacin and its major metabolite ciprofloxacin in Thai swamp buffaloes

Given the limited information available in this species, the aim of this study was to investigate the pharmacokinetic characteristics of enrofloxacin (ER) and its major metabolite ciprofloxacin (CP) in buffaloes, Bubalus bubalis. ER was administered intravenously (i.v.) or subcutaneously (s.c.) to b...

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Autores principales: RUENNARONG, Nitwarat, WONGPANIT, Kannika, SAKULTHAEW, Chainarong, GIORGI, Mario, KUMAGAI, Susumu, POAPOLATHEP, Amnart, POAPOLATHEP, Saranya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829506/
https://www.ncbi.nlm.nih.gov/pubmed/26596287
http://dx.doi.org/10.1292/jvms.15-0464
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author RUENNARONG, Nitwarat
WONGPANIT, Kannika
SAKULTHAEW, Chainarong
GIORGI, Mario
KUMAGAI, Susumu
POAPOLATHEP, Amnart
POAPOLATHEP, Saranya
author_facet RUENNARONG, Nitwarat
WONGPANIT, Kannika
SAKULTHAEW, Chainarong
GIORGI, Mario
KUMAGAI, Susumu
POAPOLATHEP, Amnart
POAPOLATHEP, Saranya
author_sort RUENNARONG, Nitwarat
collection PubMed
description Given the limited information available in this species, the aim of this study was to investigate the pharmacokinetic characteristics of enrofloxacin (ER) and its major metabolite ciprofloxacin (CP) in buffaloes, Bubalus bubalis. ER was administered intravenously (i.v.) or subcutaneously (s.c.) to buffaloes at doses of 5.0 and 7.5 mg/kg BW, and plasma, urine and fecal samples were collected until 48 hr post-administration. The concentrations of ER and CP in the plasma, urine and feces were analyzed using high-performance liquid chromatography equipped with a fluorescence detector. The plasma concentrations of ER and CP could be determined up to 24 hr and 32 hr after i.v. and s.c. administrations at doses of 5.0 and 7.5 mg/kg BW, respectively. CP concentrations were always lower than those of parental drug. The s.c. bioavailability of ER was 52.36 ± 4.24% and 72.12 ± 5.39% at doses of 5.0 and 7.5 mg/kg BW, respectively. Both ER and CP were detectable in urine and feces up to 24 hr. ER and CP were mainly excreted via the urine. Based on the pharmacokinetic data and PK-PD indices, s.c. administration of ER at doses of 5.0 and 7.5 mg/kg BW might be appropriate for the treatment of susceptible bacterial diseases in Thai swamp buffaloes.
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spelling pubmed-48295062016-04-13 Dispositions of enrofloxacin and its major metabolite ciprofloxacin in Thai swamp buffaloes RUENNARONG, Nitwarat WONGPANIT, Kannika SAKULTHAEW, Chainarong GIORGI, Mario KUMAGAI, Susumu POAPOLATHEP, Amnart POAPOLATHEP, Saranya J Vet Med Sci Pharmacology Given the limited information available in this species, the aim of this study was to investigate the pharmacokinetic characteristics of enrofloxacin (ER) and its major metabolite ciprofloxacin (CP) in buffaloes, Bubalus bubalis. ER was administered intravenously (i.v.) or subcutaneously (s.c.) to buffaloes at doses of 5.0 and 7.5 mg/kg BW, and plasma, urine and fecal samples were collected until 48 hr post-administration. The concentrations of ER and CP in the plasma, urine and feces were analyzed using high-performance liquid chromatography equipped with a fluorescence detector. The plasma concentrations of ER and CP could be determined up to 24 hr and 32 hr after i.v. and s.c. administrations at doses of 5.0 and 7.5 mg/kg BW, respectively. CP concentrations were always lower than those of parental drug. The s.c. bioavailability of ER was 52.36 ± 4.24% and 72.12 ± 5.39% at doses of 5.0 and 7.5 mg/kg BW, respectively. Both ER and CP were detectable in urine and feces up to 24 hr. ER and CP were mainly excreted via the urine. Based on the pharmacokinetic data and PK-PD indices, s.c. administration of ER at doses of 5.0 and 7.5 mg/kg BW might be appropriate for the treatment of susceptible bacterial diseases in Thai swamp buffaloes. The Japanese Society of Veterinary Science 2015-11-20 2016-03 /pmc/articles/PMC4829506/ /pubmed/26596287 http://dx.doi.org/10.1292/jvms.15-0464 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Pharmacology
RUENNARONG, Nitwarat
WONGPANIT, Kannika
SAKULTHAEW, Chainarong
GIORGI, Mario
KUMAGAI, Susumu
POAPOLATHEP, Amnart
POAPOLATHEP, Saranya
Dispositions of enrofloxacin and its major metabolite ciprofloxacin in Thai swamp buffaloes
title Dispositions of enrofloxacin and its major metabolite ciprofloxacin in Thai swamp buffaloes
title_full Dispositions of enrofloxacin and its major metabolite ciprofloxacin in Thai swamp buffaloes
title_fullStr Dispositions of enrofloxacin and its major metabolite ciprofloxacin in Thai swamp buffaloes
title_full_unstemmed Dispositions of enrofloxacin and its major metabolite ciprofloxacin in Thai swamp buffaloes
title_short Dispositions of enrofloxacin and its major metabolite ciprofloxacin in Thai swamp buffaloes
title_sort dispositions of enrofloxacin and its major metabolite ciprofloxacin in thai swamp buffaloes
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829506/
https://www.ncbi.nlm.nih.gov/pubmed/26596287
http://dx.doi.org/10.1292/jvms.15-0464
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