Mitochondrial Translocation of High Mobility Group Box 1 Facilitates LIM Kinase 2-Mediated Programmed Necrotic Neuronal Death

High mobility group box 1 (HMGB1) acts a signaling molecule regulating a wide range of inflammatory responses in extracellular space. HMGB1 also stabilizes nucleosomal structure and facilitates gene transcription. Under pathophysiological conditions, nuclear HMGB1 is immediately transported to the c...

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Detalles Bibliográficos
Autores principales: Hyun, Hye-Won, Ko, Ah-Reum, Kang, Tae-Cheon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829584/
https://www.ncbi.nlm.nih.gov/pubmed/27147971
http://dx.doi.org/10.3389/fncel.2016.00099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829584/
https://www.ncbi.nlm.nih.gov/pubmed/27147971
http://dx.doi.org/10.3389/fncel.2016.00099

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