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Differences of Variable Number Tandem Repeats in XRCC5 Promoter Are Associated with Increased or Decreased Risk of Breast Cancer in BRCA Gene Mutation Carriers

Ku80 is a subunit of the Ku heterodimer that binds to DNA double-strand break ends as part of the non-homologous end joining (NHEJ) pathway. Ku80 is also involved in homologous recombination (HR) via its interaction with BRCA1. Ku80 is encoded by the XRCC5 gene that contains a variable number tandem...

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Detalles Bibliográficos
Autores principales:	Cui, Jian, Luo, Jiangtao, Kim, Yeong C., Snyder, Carrie, Becirovic, Dina, Downs, Bradley, Lynch, Henry, Wang, San Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829605/ https://www.ncbi.nlm.nih.gov/pubmed/27148484 http://dx.doi.org/10.3389/fonc.2016.00092

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