Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2

Sirtuin 3 (Sirt3) is an NAD(+)-dependent mitochondrial deacetylase associated with superoxide dismutase 2 (SOD2)-mediated protection from oxidative stress. We have reported accelerated weight gain and impaired metabolic flexibility in atherosclerotic Sirt3(−/−) mice. Oxidative stress is a hallmark o...

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Detalles Bibliográficos
Autores principales: Winnik, Stephan, Gaul, Daniel S., Siciliani, Giovanni, Lohmann, Christine, Pasterk, Lisa, Calatayud, Natacha, Weber, Julien, Eriksson, Urs, Auwerx, Johan, van Tits, Lambertus J., Lüscher, Thomas F., Matter, Christian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829622/
https://www.ncbi.nlm.nih.gov/pubmed/27071400
http://dx.doi.org/10.1007/s00395-016-0552-7

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