Zinc Chelation Mediates the Lysosomal Disruption without Intracellular ROS Generation

We report the molecular mechanism for zinc depletion caused by TPEN (N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine) in neuroblastoma cells. The activation of p38 MAP kinase and subsequently caspase 3 is not due to or followed by redox imbalance or ROS generation, though these are commonly obser...

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Detalles Bibliográficos
Autores principales: Matias, Andreza Cândido, Manieri, Tânia Maria, Cerchiaro, Giselle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829717/
https://www.ncbi.nlm.nih.gov/pubmed/27123155
http://dx.doi.org/10.1155/2016/6724585

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