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Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis
Inflammation, as a feature of rheumatoid arthritis (RA), leads to the activation of endothelial cells (ECs). Activated ECs induce atherosclerosis through an increased expression of leukocyte adhesion molecules. Endothelial dysfunction (ED) is recognized as a failure of endothelial repair mechanisms....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829719/ https://www.ncbi.nlm.nih.gov/pubmed/27122657 http://dx.doi.org/10.1155/2016/6813016 |
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author | Yang, XueZhi Chang, Yan Wei, Wei |
author_facet | Yang, XueZhi Chang, Yan Wei, Wei |
author_sort | Yang, XueZhi |
collection | PubMed |
description | Inflammation, as a feature of rheumatoid arthritis (RA), leads to the activation of endothelial cells (ECs). Activated ECs induce atherosclerosis through an increased expression of leukocyte adhesion molecules. Endothelial dysfunction (ED) is recognized as a failure of endothelial repair mechanisms. It is also an early preclinical marker of atherosclerosis and is commonly found in RA patients. RA is now established as an independent cardiovascular risk factor, while mechanistic determinants of ED in RA are still poorly understood. An expanding body of study has shown that EC at a site of RA is both active participant and regulator of inflammatory process. Over the last decade, a role for endothelial dysfunction in RA associated with cardiovascular disease (CVD) has been hypothesized. At the same time, several maintenance drugs targeting this phenomenon have been tested, which has promising results. Assessment of endothelial function may be a useful tool to identify and monitor RA patients. |
format | Online Article Text |
id | pubmed-4829719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48297192016-04-27 Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis Yang, XueZhi Chang, Yan Wei, Wei Mediators Inflamm Review Article Inflammation, as a feature of rheumatoid arthritis (RA), leads to the activation of endothelial cells (ECs). Activated ECs induce atherosclerosis through an increased expression of leukocyte adhesion molecules. Endothelial dysfunction (ED) is recognized as a failure of endothelial repair mechanisms. It is also an early preclinical marker of atherosclerosis and is commonly found in RA patients. RA is now established as an independent cardiovascular risk factor, while mechanistic determinants of ED in RA are still poorly understood. An expanding body of study has shown that EC at a site of RA is both active participant and regulator of inflammatory process. Over the last decade, a role for endothelial dysfunction in RA associated with cardiovascular disease (CVD) has been hypothesized. At the same time, several maintenance drugs targeting this phenomenon have been tested, which has promising results. Assessment of endothelial function may be a useful tool to identify and monitor RA patients. Hindawi Publishing Corporation 2016 2016-03-30 /pmc/articles/PMC4829719/ /pubmed/27122657 http://dx.doi.org/10.1155/2016/6813016 Text en Copyright © 2016 XueZhi Yang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yang, XueZhi Chang, Yan Wei, Wei Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis |
title | Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis |
title_full | Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis |
title_fullStr | Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis |
title_full_unstemmed | Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis |
title_short | Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis |
title_sort | endothelial dysfunction and inflammation: immunity in rheumatoid arthritis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829719/ https://www.ncbi.nlm.nih.gov/pubmed/27122657 http://dx.doi.org/10.1155/2016/6813016 |
work_keys_str_mv | AT yangxuezhi endothelialdysfunctionandinflammationimmunityinrheumatoidarthritis AT changyan endothelialdysfunctionandinflammationimmunityinrheumatoidarthritis AT weiwei endothelialdysfunctionandinflammationimmunityinrheumatoidarthritis |