Cargando…

Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis

Inflammation, as a feature of rheumatoid arthritis (RA), leads to the activation of endothelial cells (ECs). Activated ECs induce atherosclerosis through an increased expression of leukocyte adhesion molecules. Endothelial dysfunction (ED) is recognized as a failure of endothelial repair mechanisms....

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, XueZhi, Chang, Yan, Wei, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829719/
https://www.ncbi.nlm.nih.gov/pubmed/27122657
http://dx.doi.org/10.1155/2016/6813016
_version_ 1782426788802068480
author Yang, XueZhi
Chang, Yan
Wei, Wei
author_facet Yang, XueZhi
Chang, Yan
Wei, Wei
author_sort Yang, XueZhi
collection PubMed
description Inflammation, as a feature of rheumatoid arthritis (RA), leads to the activation of endothelial cells (ECs). Activated ECs induce atherosclerosis through an increased expression of leukocyte adhesion molecules. Endothelial dysfunction (ED) is recognized as a failure of endothelial repair mechanisms. It is also an early preclinical marker of atherosclerosis and is commonly found in RA patients. RA is now established as an independent cardiovascular risk factor, while mechanistic determinants of ED in RA are still poorly understood. An expanding body of study has shown that EC at a site of RA is both active participant and regulator of inflammatory process. Over the last decade, a role for endothelial dysfunction in RA associated with cardiovascular disease (CVD) has been hypothesized. At the same time, several maintenance drugs targeting this phenomenon have been tested, which has promising results. Assessment of endothelial function may be a useful tool to identify and monitor RA patients.
format Online
Article
Text
id pubmed-4829719
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-48297192016-04-27 Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis Yang, XueZhi Chang, Yan Wei, Wei Mediators Inflamm Review Article Inflammation, as a feature of rheumatoid arthritis (RA), leads to the activation of endothelial cells (ECs). Activated ECs induce atherosclerosis through an increased expression of leukocyte adhesion molecules. Endothelial dysfunction (ED) is recognized as a failure of endothelial repair mechanisms. It is also an early preclinical marker of atherosclerosis and is commonly found in RA patients. RA is now established as an independent cardiovascular risk factor, while mechanistic determinants of ED in RA are still poorly understood. An expanding body of study has shown that EC at a site of RA is both active participant and regulator of inflammatory process. Over the last decade, a role for endothelial dysfunction in RA associated with cardiovascular disease (CVD) has been hypothesized. At the same time, several maintenance drugs targeting this phenomenon have been tested, which has promising results. Assessment of endothelial function may be a useful tool to identify and monitor RA patients. Hindawi Publishing Corporation 2016 2016-03-30 /pmc/articles/PMC4829719/ /pubmed/27122657 http://dx.doi.org/10.1155/2016/6813016 Text en Copyright © 2016 XueZhi Yang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yang, XueZhi
Chang, Yan
Wei, Wei
Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis
title Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis
title_full Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis
title_fullStr Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis
title_full_unstemmed Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis
title_short Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis
title_sort endothelial dysfunction and inflammation: immunity in rheumatoid arthritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829719/
https://www.ncbi.nlm.nih.gov/pubmed/27122657
http://dx.doi.org/10.1155/2016/6813016
work_keys_str_mv AT yangxuezhi endothelialdysfunctionandinflammationimmunityinrheumatoidarthritis
AT changyan endothelialdysfunctionandinflammationimmunityinrheumatoidarthritis
AT weiwei endothelialdysfunctionandinflammationimmunityinrheumatoidarthritis