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The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes

Objective. We studied the prevalence of nonalcoholic fatty liver disease (NAFLD) and its clinical correlates in a population of patients with type 2 diabetes mellitus (T2DM). Methods. Clinical data of 94,577 T2DM patients were retrieved from 160 diabetes clinics in Italy in a standardized format and...

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Autores principales: Forlani, Gabriele, Giorda, Carlo, Manti, Roberta, Mazzella, Natalia, De Cosmo, Salvatore, Rossi, Maria Chiara, Nicolucci, Antonio, Di Bartolo, Paolo, Ceriello, Antonio, Guida, Pietro, Study Group, AMD-Annals
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829721/
https://www.ncbi.nlm.nih.gov/pubmed/27123461
http://dx.doi.org/10.1155/2016/2931985
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author Forlani, Gabriele
Giorda, Carlo
Manti, Roberta
Mazzella, Natalia
De Cosmo, Salvatore
Rossi, Maria Chiara
Nicolucci, Antonio
Di Bartolo, Paolo
Ceriello, Antonio
Guida, Pietro
Study Group, AMD-Annals
author_facet Forlani, Gabriele
Giorda, Carlo
Manti, Roberta
Mazzella, Natalia
De Cosmo, Salvatore
Rossi, Maria Chiara
Nicolucci, Antonio
Di Bartolo, Paolo
Ceriello, Antonio
Guida, Pietro
Study Group, AMD-Annals
author_sort Forlani, Gabriele
collection PubMed
description Objective. We studied the prevalence of nonalcoholic fatty liver disease (NAFLD) and its clinical correlates in a population of patients with type 2 diabetes mellitus (T2DM). Methods. Clinical data of 94,577 T2DM patients were retrieved from 160 diabetes clinics in Italy in a standardized format and centrally analyzed anonymously. After exclusion of 5967 cases (high or uncertain alcohol intake), in 38,880 the Fatty Liver Index (FLI) was used as a proxy for the diagnosis of NAFLD. Factors associated with FLI assessed NAFLD (FLI-NAFLD) were evaluated through multivariate analysis. Results. FLI-NAFLD was present in 59.6% of patients. Compared to non-NAFLD, FLI-NAFLD was associated with impairment in renal function, higher albumin excretion, HbA1c and blood pressure, lower HDL cholesterol, and poorer quality of care. ALT was within normal limits in 73.6% of FLI-NAFLD patients (45.6% if the updated reference values were used). The prevalence of FLI-NAFLD did not differ if the whole sample (94,577 cases) was examined, irrespective of alcohol intake. Conclusions. FLI-NAFLD was present in the majority of T2DM patients of our sample and metabolic derangement, not alcohol consumption, was mainly associated with the disease. FLI-NAFLD patients have a worse metabolic profile. ALT levels are not predictive of NAFLD.
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spelling pubmed-48297212016-04-27 The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes Forlani, Gabriele Giorda, Carlo Manti, Roberta Mazzella, Natalia De Cosmo, Salvatore Rossi, Maria Chiara Nicolucci, Antonio Di Bartolo, Paolo Ceriello, Antonio Guida, Pietro Study Group, AMD-Annals J Diabetes Res Research Article Objective. We studied the prevalence of nonalcoholic fatty liver disease (NAFLD) and its clinical correlates in a population of patients with type 2 diabetes mellitus (T2DM). Methods. Clinical data of 94,577 T2DM patients were retrieved from 160 diabetes clinics in Italy in a standardized format and centrally analyzed anonymously. After exclusion of 5967 cases (high or uncertain alcohol intake), in 38,880 the Fatty Liver Index (FLI) was used as a proxy for the diagnosis of NAFLD. Factors associated with FLI assessed NAFLD (FLI-NAFLD) were evaluated through multivariate analysis. Results. FLI-NAFLD was present in 59.6% of patients. Compared to non-NAFLD, FLI-NAFLD was associated with impairment in renal function, higher albumin excretion, HbA1c and blood pressure, lower HDL cholesterol, and poorer quality of care. ALT was within normal limits in 73.6% of FLI-NAFLD patients (45.6% if the updated reference values were used). The prevalence of FLI-NAFLD did not differ if the whole sample (94,577 cases) was examined, irrespective of alcohol intake. Conclusions. FLI-NAFLD was present in the majority of T2DM patients of our sample and metabolic derangement, not alcohol consumption, was mainly associated with the disease. FLI-NAFLD patients have a worse metabolic profile. ALT levels are not predictive of NAFLD. Hindawi Publishing Corporation 2016 2016-03-30 /pmc/articles/PMC4829721/ /pubmed/27123461 http://dx.doi.org/10.1155/2016/2931985 Text en Copyright © 2016 Gabriele Forlani et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Forlani, Gabriele
Giorda, Carlo
Manti, Roberta
Mazzella, Natalia
De Cosmo, Salvatore
Rossi, Maria Chiara
Nicolucci, Antonio
Di Bartolo, Paolo
Ceriello, Antonio
Guida, Pietro
Study Group, AMD-Annals
The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes
title The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes
title_full The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes
title_fullStr The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes
title_full_unstemmed The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes
title_short The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes
title_sort burden of nafld and its characteristics in a nationwide population with type 2 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829721/
https://www.ncbi.nlm.nih.gov/pubmed/27123461
http://dx.doi.org/10.1155/2016/2931985
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