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A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration

The traditional production methods of porous magnesium scaffolds are difficult to accurately control the pore morphologies and simultaneously obtain appropriate mechanical properties. In this work, two open-porous magnesium scaffolds with different pore size but in the nearly same porosity are succe...

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Autores principales: Cheng, Meng-qi, Wahafu, Tuerhongjiang, Jiang, Guo-feng, Liu, Wei, Qiao, Yu-qin, Peng, Xiao-chun, Cheng, Tao, Zhang, Xian-long, He, Guo, Liu, Xuan-yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829853/
https://www.ncbi.nlm.nih.gov/pubmed/27071777
http://dx.doi.org/10.1038/srep24134
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author Cheng, Meng-qi
Wahafu, Tuerhongjiang
Jiang, Guo-feng
Liu, Wei
Qiao, Yu-qin
Peng, Xiao-chun
Cheng, Tao
Zhang, Xian-long
He, Guo
Liu, Xuan-yong
author_facet Cheng, Meng-qi
Wahafu, Tuerhongjiang
Jiang, Guo-feng
Liu, Wei
Qiao, Yu-qin
Peng, Xiao-chun
Cheng, Tao
Zhang, Xian-long
He, Guo
Liu, Xuan-yong
author_sort Cheng, Meng-qi
collection PubMed
description The traditional production methods of porous magnesium scaffolds are difficult to accurately control the pore morphologies and simultaneously obtain appropriate mechanical properties. In this work, two open-porous magnesium scaffolds with different pore size but in the nearly same porosity are successfully fabricated with high-purity Mg ingots through the titanium wire space holder (TWSH) method. The porosity and pore size can be easily, precisely and individually controlled, as well as the mechanical properties also can be regulated to be within the range of human cancellous bone by changing the orientation of pores without sacrifice the requisite porous structures. In vitro cell tests indicate that the scaffolds have good cytocompatibility and osteoblastic differentiation properties. In vivo findings demonstrate that both scaffolds exhibit acceptable inflammatory responses and can be almost fully degraded and replaced by newly formed bone. More importantly, under the same porosity, the scaffolds with larger pore size can promote early vascularization and up-regulate collagen type 1 and OPN expression, leading to higher bone mass and more mature bone formation. In conclusion, a new method is introduced to develop an open-porous magnesium scaffold with controllable microstructures and mechanical properties, which has great potential clinical application for bone reconstruction in the future.
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spelling pubmed-48298532016-04-19 A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration Cheng, Meng-qi Wahafu, Tuerhongjiang Jiang, Guo-feng Liu, Wei Qiao, Yu-qin Peng, Xiao-chun Cheng, Tao Zhang, Xian-long He, Guo Liu, Xuan-yong Sci Rep Article The traditional production methods of porous magnesium scaffolds are difficult to accurately control the pore morphologies and simultaneously obtain appropriate mechanical properties. In this work, two open-porous magnesium scaffolds with different pore size but in the nearly same porosity are successfully fabricated with high-purity Mg ingots through the titanium wire space holder (TWSH) method. The porosity and pore size can be easily, precisely and individually controlled, as well as the mechanical properties also can be regulated to be within the range of human cancellous bone by changing the orientation of pores without sacrifice the requisite porous structures. In vitro cell tests indicate that the scaffolds have good cytocompatibility and osteoblastic differentiation properties. In vivo findings demonstrate that both scaffolds exhibit acceptable inflammatory responses and can be almost fully degraded and replaced by newly formed bone. More importantly, under the same porosity, the scaffolds with larger pore size can promote early vascularization and up-regulate collagen type 1 and OPN expression, leading to higher bone mass and more mature bone formation. In conclusion, a new method is introduced to develop an open-porous magnesium scaffold with controllable microstructures and mechanical properties, which has great potential clinical application for bone reconstruction in the future. Nature Publishing Group 2016-04-13 /pmc/articles/PMC4829853/ /pubmed/27071777 http://dx.doi.org/10.1038/srep24134 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Cheng, Meng-qi
Wahafu, Tuerhongjiang
Jiang, Guo-feng
Liu, Wei
Qiao, Yu-qin
Peng, Xiao-chun
Cheng, Tao
Zhang, Xian-long
He, Guo
Liu, Xuan-yong
A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration
title A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration
title_full A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration
title_fullStr A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration
title_full_unstemmed A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration
title_short A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration
title_sort novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829853/
https://www.ncbi.nlm.nih.gov/pubmed/27071777
http://dx.doi.org/10.1038/srep24134
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