Islands of spatially discordant APD alternans underlie arrhythmogenesis by promoting electrotonic dyssynchrony in models of fibrotic rat ventricular myocardium

Fibrosis and altered gap junctional coupling are key features of ventricular remodelling and are associated with abnormal electrical impulse generation and propagation. Such abnormalities predispose to reentrant electrical activity in the heart. In the absence of tissue heterogeneity, high-frequency...

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Detalles Bibliográficos
Autores principales: Majumder, Rupamanjari, Engels, Marc C., de Vries, Antoine A. F., Panfilov, Alexander V., Pijnappels, Daniël A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829862/
https://www.ncbi.nlm.nih.gov/pubmed/27072041
http://dx.doi.org/10.1038/srep24334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829862/
https://www.ncbi.nlm.nih.gov/pubmed/27072041
http://dx.doi.org/10.1038/srep24334

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