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GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response

Cancer-associated fibroblasts (CAFs) contribute to the malignant aggressiveness through secreted factors like IL1β, which may drive pro-tumorigenic inflammatory phenotypes mainly acting via the cognate receptor named IL1R1. Here, we demonstrate that signalling mediated by the G protein estrogen rece...

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Detalles Bibliográficos
Autores principales:	De Marco, Paola, Lappano, Rosamaria, Francesco, Ernestina Marianna De, Cirillo, Francesca, Pupo, Marco, Avino, Silvia, Vivacqua, Adele, Abonante, Sergio, Picard, Didier, Maggiolini, Marcello
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829876/ https://www.ncbi.nlm.nih.gov/pubmed/27072893 http://dx.doi.org/10.1038/srep24354

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