Effects of Common Pesticides on Prostaglandin D2 (PGD2) Inhibition in SC5 Mouse Sertoli Cells, Evidence of Binding at the COX-2 Active Site, and Implications for Endocrine Disruption

BACKGROUND: There are concerns that diminished prostaglandin action in fetal life could increase the risk of congenital malformations. Many endocrine-disrupting chemicals have been found to suppress prostaglandin synthesis, but to our knowledge, pesticides have never been tested for these effects. O...

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Autores principales: Kugathas, Subramaniam, Audouze, Karine, Ermler, Sibylle, Orton, Frances, Rosivatz, Erika, Scholze, Martin, Kortenkamp, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829986/
https://www.ncbi.nlm.nih.gov/pubmed/26359731
http://dx.doi.org/10.1289/ehp.1409544

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