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Cardiovascular magnetic resonance reference ranges for the heart and aorta in Chinese at 3T

BACKGROUND: Cardiovascular magnetic resonance (CMR) reference ranges have not been well established in Chinese. Here we determined normal cardiac and aortic reference ranges in healthy Singaporean Chinese and investigated how these data might affect clinical interpretation of CMR scans. METHODS: In...

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Autores principales: Le, Thu-Thao, Tan, Ru San, De Deyn, Michelle, Goh, Elizabeth Pee Chong, Han, Yiying, Leong, Bao Ru, Cook, Stuart Alexander, Chin, Calvin Woon-Loong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830061/
https://www.ncbi.nlm.nih.gov/pubmed/27071974
http://dx.doi.org/10.1186/s12968-016-0236-3
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author Le, Thu-Thao
Tan, Ru San
De Deyn, Michelle
Goh, Elizabeth Pee Chong
Han, Yiying
Leong, Bao Ru
Cook, Stuart Alexander
Chin, Calvin Woon-Loong
author_facet Le, Thu-Thao
Tan, Ru San
De Deyn, Michelle
Goh, Elizabeth Pee Chong
Han, Yiying
Leong, Bao Ru
Cook, Stuart Alexander
Chin, Calvin Woon-Loong
author_sort Le, Thu-Thao
collection PubMed
description BACKGROUND: Cardiovascular magnetic resonance (CMR) reference ranges have not been well established in Chinese. Here we determined normal cardiac and aortic reference ranges in healthy Singaporean Chinese and investigated how these data might affect clinical interpretation of CMR scans. METHODS: In 180 healthy Singaporean Chinese (20 to 69 years old; males, n = 91), comprehensive cardiac assessment was performed using the steady state free precision technique (3T Ingenia, Philips) and images were analysed by two independent observers (CMR42, Circle Cardiovascular Imaging). Measurements were internally validated using standardized approaches: left ventricular mass (LVM) was measured in diastole and systole (with and without papillary muscles) and stroke volumes were compared in both ventricles. All reference ranges were stratified by sex and age; and “indeterminate/borderline” regions were defined statistically at the limits of the normal reference ranges. Results were compared with clinical measurements reported in the same individuals. RESULTS: LVM was equivalent in both phases (mean difference 3.0 ± 2.5 g; P = 0.22) and stroke volumes were not significantly different in the left and right ventricles (P = 0.91). Compared to females, males had larger left and right ventricular volumes (P < 0.001 for all). Indexed LVM was significantly higher in males compared to females (50 ± 7 versus 38 ± 5 g/m(2), respectively; P < 0.001). Overall, papillary muscles accounted for only ~2 % of the total LVM. Indexed atrial sizes and aortic root dimensions were similar between males and females (P > 0.05 for all measures). In both sexes, age correlated negatively with left and right ventricular volumes; and positively with aortic sinus and sinotubular junction diameters (P < 0.0001 for all). There was excellent agreement in indexed stroke volumes in the left and right ventricles (0.1±5.7mL/m(2), 0.7±6.2 mL/m(2), respectively), LVM (0.6±6.4g/m(2)), atrial sizes and aortic root dimensions between values reported in clinical reports and our measured reference ranges. CONCLUSIONS: Comprehensive sex and age-corrected CMR reference ranges at 3T have been established in Singaporean Chinese. This is an important step for clinical practice and research studies of the heart and aorta in Asia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12968-016-0236-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-48300612016-04-14 Cardiovascular magnetic resonance reference ranges for the heart and aorta in Chinese at 3T Le, Thu-Thao Tan, Ru San De Deyn, Michelle Goh, Elizabeth Pee Chong Han, Yiying Leong, Bao Ru Cook, Stuart Alexander Chin, Calvin Woon-Loong J Cardiovasc Magn Reson Research BACKGROUND: Cardiovascular magnetic resonance (CMR) reference ranges have not been well established in Chinese. Here we determined normal cardiac and aortic reference ranges in healthy Singaporean Chinese and investigated how these data might affect clinical interpretation of CMR scans. METHODS: In 180 healthy Singaporean Chinese (20 to 69 years old; males, n = 91), comprehensive cardiac assessment was performed using the steady state free precision technique (3T Ingenia, Philips) and images were analysed by two independent observers (CMR42, Circle Cardiovascular Imaging). Measurements were internally validated using standardized approaches: left ventricular mass (LVM) was measured in diastole and systole (with and without papillary muscles) and stroke volumes were compared in both ventricles. All reference ranges were stratified by sex and age; and “indeterminate/borderline” regions were defined statistically at the limits of the normal reference ranges. Results were compared with clinical measurements reported in the same individuals. RESULTS: LVM was equivalent in both phases (mean difference 3.0 ± 2.5 g; P = 0.22) and stroke volumes were not significantly different in the left and right ventricles (P = 0.91). Compared to females, males had larger left and right ventricular volumes (P < 0.001 for all). Indexed LVM was significantly higher in males compared to females (50 ± 7 versus 38 ± 5 g/m(2), respectively; P < 0.001). Overall, papillary muscles accounted for only ~2 % of the total LVM. Indexed atrial sizes and aortic root dimensions were similar between males and females (P > 0.05 for all measures). In both sexes, age correlated negatively with left and right ventricular volumes; and positively with aortic sinus and sinotubular junction diameters (P < 0.0001 for all). There was excellent agreement in indexed stroke volumes in the left and right ventricles (0.1±5.7mL/m(2), 0.7±6.2 mL/m(2), respectively), LVM (0.6±6.4g/m(2)), atrial sizes and aortic root dimensions between values reported in clinical reports and our measured reference ranges. CONCLUSIONS: Comprehensive sex and age-corrected CMR reference ranges at 3T have been established in Singaporean Chinese. This is an important step for clinical practice and research studies of the heart and aorta in Asia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12968-016-0236-3) contains supplementary material, which is available to authorized users. BioMed Central 2016-04-12 /pmc/articles/PMC4830061/ /pubmed/27071974 http://dx.doi.org/10.1186/s12968-016-0236-3 Text en © Le et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Le, Thu-Thao
Tan, Ru San
De Deyn, Michelle
Goh, Elizabeth Pee Chong
Han, Yiying
Leong, Bao Ru
Cook, Stuart Alexander
Chin, Calvin Woon-Loong
Cardiovascular magnetic resonance reference ranges for the heart and aorta in Chinese at 3T
title Cardiovascular magnetic resonance reference ranges for the heart and aorta in Chinese at 3T
title_full Cardiovascular magnetic resonance reference ranges for the heart and aorta in Chinese at 3T
title_fullStr Cardiovascular magnetic resonance reference ranges for the heart and aorta in Chinese at 3T
title_full_unstemmed Cardiovascular magnetic resonance reference ranges for the heart and aorta in Chinese at 3T
title_short Cardiovascular magnetic resonance reference ranges for the heart and aorta in Chinese at 3T
title_sort cardiovascular magnetic resonance reference ranges for the heart and aorta in chinese at 3t
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830061/
https://www.ncbi.nlm.nih.gov/pubmed/27071974
http://dx.doi.org/10.1186/s12968-016-0236-3
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