Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis

Annexins are Ca(2+)-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells...

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Detalles Bibliográficos
Autores principales: Mirsaeidi, Mehdi, Gidfar, Sanaz, Vu, Ann, Schraufnagel, Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830063/
https://www.ncbi.nlm.nih.gov/pubmed/27071553
http://dx.doi.org/10.1186/s12967-016-0843-7
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author Mirsaeidi, Mehdi
Gidfar, Sanaz
Vu, Ann
Schraufnagel, Dean
author_facet Mirsaeidi, Mehdi
Gidfar, Sanaz
Vu, Ann
Schraufnagel, Dean
author_sort Mirsaeidi, Mehdi
collection PubMed
description Annexins are Ca(2+)-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells may be due to alterations in apoptosis. Immune cells with a specific mutation at protein location 230 are resistant to apoptosis and consequently have continued effects on inflammation and progression of sarcoidosis. The mechanism of action of annexin A11 may be based upon alterations in delivering calcium to two different apoptosis pathways (caspase and P53).
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spelling pubmed-48300632016-04-14 Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis Mirsaeidi, Mehdi Gidfar, Sanaz Vu, Ann Schraufnagel, Dean J Transl Med Review Annexins are Ca(2+)-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells may be due to alterations in apoptosis. Immune cells with a specific mutation at protein location 230 are resistant to apoptosis and consequently have continued effects on inflammation and progression of sarcoidosis. The mechanism of action of annexin A11 may be based upon alterations in delivering calcium to two different apoptosis pathways (caspase and P53). BioMed Central 2016-04-12 /pmc/articles/PMC4830063/ /pubmed/27071553 http://dx.doi.org/10.1186/s12967-016-0843-7 Text en © Mirsaeidi et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Mirsaeidi, Mehdi
Gidfar, Sanaz
Vu, Ann
Schraufnagel, Dean
Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis
title Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis
title_full Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis
title_fullStr Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis
title_full_unstemmed Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis
title_short Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis
title_sort annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830063/
https://www.ncbi.nlm.nih.gov/pubmed/27071553
http://dx.doi.org/10.1186/s12967-016-0843-7
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