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Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia

BACKGROUND: The constitutive hyper-activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways has frequently been associated with acute myeloid leukemia (AML). While many inhibitors targeting these pathways have been developed, t...

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Detalles Bibliográficos
Autores principales:	Gao, Yanan, Gao, Juan, Li, Minghao, Zheng, Yawei, Wang, Yajie, Zhang, Hongyan, Wang, Weili, Chu, Yajing, Wang, Xiaomin, Xu, Mingjiang, Cheng, Tao, Ju, Zhenyu, Yuan, Weiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830070/ https://www.ncbi.nlm.nih.gov/pubmed/27071307 http://dx.doi.org/10.1186/s13045-016-0264-3

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