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Fecal calprotectin level correlated with both endoscopic severity and disease extent in ulcerative colitis

BACKGROUND: The relationship between fecal calprotectin (FC) and disease extent in ulcerative colitis (UC) has not been fully elucidated. The aim of this study was to clarify the correlation of FC with disease extent and severity in UC patients. METHODS: UC patients scheduled to undergo an ileocolon...

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Autores principales: Kawashima, Kousaku, Ishihara, Shunji, Yuki, Takafumi, Fukuba, Nobuhiko, Oshima, Naoki, Kazumori, Hideaki, Sonoyama, Hiroki, Yamashita, Noritsugu, Tada, Yasumasa, Kusunoki, Ryusaku, Oka, Akihiko, Mishima, Yoshiyuki, Moriyama, Ichiro, Kinoshita, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830074/
https://www.ncbi.nlm.nih.gov/pubmed/27071448
http://dx.doi.org/10.1186/s12876-016-0462-z
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author Kawashima, Kousaku
Ishihara, Shunji
Yuki, Takafumi
Fukuba, Nobuhiko
Oshima, Naoki
Kazumori, Hideaki
Sonoyama, Hiroki
Yamashita, Noritsugu
Tada, Yasumasa
Kusunoki, Ryusaku
Oka, Akihiko
Mishima, Yoshiyuki
Moriyama, Ichiro
Kinoshita, Yoshikazu
author_facet Kawashima, Kousaku
Ishihara, Shunji
Yuki, Takafumi
Fukuba, Nobuhiko
Oshima, Naoki
Kazumori, Hideaki
Sonoyama, Hiroki
Yamashita, Noritsugu
Tada, Yasumasa
Kusunoki, Ryusaku
Oka, Akihiko
Mishima, Yoshiyuki
Moriyama, Ichiro
Kinoshita, Yoshikazu
author_sort Kawashima, Kousaku
collection PubMed
description BACKGROUND: The relationship between fecal calprotectin (FC) and disease extent in ulcerative colitis (UC) has not been fully elucidated. The aim of this study was to clarify the correlation of FC with disease extent and severity in UC patients. METHODS: UC patients scheduled to undergo an ileocolonoscopy were enrolled and fecal samples for FC measurement were collected prior to the procedure. A Mayo endoscopic subscore (MES) was determined for each of 5 colonic segments. To evaluate the association of FC with extent of affected mucosa as well as disease severity, we assessed the correlation of FC level with the sum of MES (S-MES) for the 5 colonic segments as compared to the maximum score of MES (M-MES). RESULTS: FC measurements in conjunction with findings from 136 complete colonoscopies in 102 UC patients were evaluated. FC level showed a stronger correlation with S-MES (correlation coefficient r = 0.86, p < 0.001) as compared to M-MES (r = 0.79, p < 0.001). In patients with an M-MES of 1, 2, and 3, FC level showed a significant correlation with S-MES (r = 0.67, p < 0.001; r = 0.70, p < 0.001; r = 0.47, p = 0.04, respectively). Our findings indicate that FC level is elevated in patients with greater areas of affected mucosa even in those with the same M-MES value. CONCLUSIONS: FC level was shown to be correlated with the extent of affected mucosa as well as severity in UC patients, thus it is useful for precise assessment of mucosal inflammation.
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spelling pubmed-48300742016-04-14 Fecal calprotectin level correlated with both endoscopic severity and disease extent in ulcerative colitis Kawashima, Kousaku Ishihara, Shunji Yuki, Takafumi Fukuba, Nobuhiko Oshima, Naoki Kazumori, Hideaki Sonoyama, Hiroki Yamashita, Noritsugu Tada, Yasumasa Kusunoki, Ryusaku Oka, Akihiko Mishima, Yoshiyuki Moriyama, Ichiro Kinoshita, Yoshikazu BMC Gastroenterol Research Article BACKGROUND: The relationship between fecal calprotectin (FC) and disease extent in ulcerative colitis (UC) has not been fully elucidated. The aim of this study was to clarify the correlation of FC with disease extent and severity in UC patients. METHODS: UC patients scheduled to undergo an ileocolonoscopy were enrolled and fecal samples for FC measurement were collected prior to the procedure. A Mayo endoscopic subscore (MES) was determined for each of 5 colonic segments. To evaluate the association of FC with extent of affected mucosa as well as disease severity, we assessed the correlation of FC level with the sum of MES (S-MES) for the 5 colonic segments as compared to the maximum score of MES (M-MES). RESULTS: FC measurements in conjunction with findings from 136 complete colonoscopies in 102 UC patients were evaluated. FC level showed a stronger correlation with S-MES (correlation coefficient r = 0.86, p < 0.001) as compared to M-MES (r = 0.79, p < 0.001). In patients with an M-MES of 1, 2, and 3, FC level showed a significant correlation with S-MES (r = 0.67, p < 0.001; r = 0.70, p < 0.001; r = 0.47, p = 0.04, respectively). Our findings indicate that FC level is elevated in patients with greater areas of affected mucosa even in those with the same M-MES value. CONCLUSIONS: FC level was shown to be correlated with the extent of affected mucosa as well as severity in UC patients, thus it is useful for precise assessment of mucosal inflammation. BioMed Central 2016-04-12 /pmc/articles/PMC4830074/ /pubmed/27071448 http://dx.doi.org/10.1186/s12876-016-0462-z Text en © Kawashima et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Kawashima, Kousaku
Ishihara, Shunji
Yuki, Takafumi
Fukuba, Nobuhiko
Oshima, Naoki
Kazumori, Hideaki
Sonoyama, Hiroki
Yamashita, Noritsugu
Tada, Yasumasa
Kusunoki, Ryusaku
Oka, Akihiko
Mishima, Yoshiyuki
Moriyama, Ichiro
Kinoshita, Yoshikazu
Fecal calprotectin level correlated with both endoscopic severity and disease extent in ulcerative colitis
title Fecal calprotectin level correlated with both endoscopic severity and disease extent in ulcerative colitis
title_full Fecal calprotectin level correlated with both endoscopic severity and disease extent in ulcerative colitis
title_fullStr Fecal calprotectin level correlated with both endoscopic severity and disease extent in ulcerative colitis
title_full_unstemmed Fecal calprotectin level correlated with both endoscopic severity and disease extent in ulcerative colitis
title_short Fecal calprotectin level correlated with both endoscopic severity and disease extent in ulcerative colitis
title_sort fecal calprotectin level correlated with both endoscopic severity and disease extent in ulcerative colitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830074/
https://www.ncbi.nlm.nih.gov/pubmed/27071448
http://dx.doi.org/10.1186/s12876-016-0462-z
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