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Factors Associated with Premature Hair Graying in a Young Indian Population

CONTEXT: Although the primary cause of premature hair graying (PHG) is considered to be genetic, certain environmental factors also play a role. Trace element deficiencies such as Vitamin B12, Vitamin D3, and calcium may also be associated with PHG. However, India-specific data are relatively sparse...

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Autores principales: Chakrabarty, Swagata, Krishnappa, Prafulla G, Gowda, Dinesh G, Hiremath, Jyothi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830165/
https://www.ncbi.nlm.nih.gov/pubmed/27127369
http://dx.doi.org/10.4103/0974-7753.179384
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author Chakrabarty, Swagata
Krishnappa, Prafulla G
Gowda, Dinesh G
Hiremath, Jyothi
author_facet Chakrabarty, Swagata
Krishnappa, Prafulla G
Gowda, Dinesh G
Hiremath, Jyothi
author_sort Chakrabarty, Swagata
collection PubMed
description CONTEXT: Although the primary cause of premature hair graying (PHG) is considered to be genetic, certain environmental factors also play a role. Trace element deficiencies such as Vitamin B12, Vitamin D3, and calcium may also be associated with PHG. However, India-specific data are relatively sparse. AIMS: The present study aimed at identifying factors associated with PHG in Indian patients. SETTINGS AND DESIGN: A case–control study was conducted at a trichology clinic in Bengaluru between October 2013 and April 2014 with a total of 37 cases of PHG and 37 age- and gender-matched controls. MATERIALS AND METHODS: A total of 100 subjects were investigated for various parameters such as hemoglobin, serum ferritin, zinc, copper, calcium, Vitamin B12, and Vitamin D after obtaining informed consent. STATISTICAL ANALYSIS USED: Chi-square test was used to compare proportions between groups. Means were compared between groups using Student's t-test. RESULTS: Serum ferritin levels were lower in patients with PHG as compared to the control group and the differences were statistically significant (P < 0.001). Furthermore, as compared to the controls, patients with PHG had lower serum Vitamin B12 levels (P < 0.001). Individuals with PHG had significantly lower levels of high-density lipoprotein cholesterol (HDL-C) as compared to the control group (P < 0.001). Significant proportions of patients with PHG had a sedentary lifestyle and admitted to having irregular eating habits. CONCLUSION: PHG is associated with low serum ferritin, Vitamin B12, and HDL-C levels in Indian patients aged <25 years. However, studies with large sample sizes may be required to conclusively define these putative associations.
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spelling pubmed-48301652016-04-28 Factors Associated with Premature Hair Graying in a Young Indian Population Chakrabarty, Swagata Krishnappa, Prafulla G Gowda, Dinesh G Hiremath, Jyothi Int J Trichology Original Article CONTEXT: Although the primary cause of premature hair graying (PHG) is considered to be genetic, certain environmental factors also play a role. Trace element deficiencies such as Vitamin B12, Vitamin D3, and calcium may also be associated with PHG. However, India-specific data are relatively sparse. AIMS: The present study aimed at identifying factors associated with PHG in Indian patients. SETTINGS AND DESIGN: A case–control study was conducted at a trichology clinic in Bengaluru between October 2013 and April 2014 with a total of 37 cases of PHG and 37 age- and gender-matched controls. MATERIALS AND METHODS: A total of 100 subjects were investigated for various parameters such as hemoglobin, serum ferritin, zinc, copper, calcium, Vitamin B12, and Vitamin D after obtaining informed consent. STATISTICAL ANALYSIS USED: Chi-square test was used to compare proportions between groups. Means were compared between groups using Student's t-test. RESULTS: Serum ferritin levels were lower in patients with PHG as compared to the control group and the differences were statistically significant (P < 0.001). Furthermore, as compared to the controls, patients with PHG had lower serum Vitamin B12 levels (P < 0.001). Individuals with PHG had significantly lower levels of high-density lipoprotein cholesterol (HDL-C) as compared to the control group (P < 0.001). Significant proportions of patients with PHG had a sedentary lifestyle and admitted to having irregular eating habits. CONCLUSION: PHG is associated with low serum ferritin, Vitamin B12, and HDL-C levels in Indian patients aged <25 years. However, studies with large sample sizes may be required to conclusively define these putative associations. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4830165/ /pubmed/27127369 http://dx.doi.org/10.4103/0974-7753.179384 Text en Copyright: © International Journal of Trichology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Chakrabarty, Swagata
Krishnappa, Prafulla G
Gowda, Dinesh G
Hiremath, Jyothi
Factors Associated with Premature Hair Graying in a Young Indian Population
title Factors Associated with Premature Hair Graying in a Young Indian Population
title_full Factors Associated with Premature Hair Graying in a Young Indian Population
title_fullStr Factors Associated with Premature Hair Graying in a Young Indian Population
title_full_unstemmed Factors Associated with Premature Hair Graying in a Young Indian Population
title_short Factors Associated with Premature Hair Graying in a Young Indian Population
title_sort factors associated with premature hair graying in a young indian population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830165/
https://www.ncbi.nlm.nih.gov/pubmed/27127369
http://dx.doi.org/10.4103/0974-7753.179384
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