Stabilization of the thermolabile variant S113L of carnitine palmitoyltransferase II

OBJECTIVE: Muscle carnitine palmitoyltransferase (CPT) II deficiency, the most common defect of lipid metabolism in muscle, is characterized by attacks of myoglobinuria without persistent muscle weakness. METHODS: His(6)-N-hCPT2 (wild-type) and His(6)-N-hCPT2/S113L (variant) were produced recombinan...

Descripción completa

Detalles Bibliográficos
Autores principales: Motlagh, Leila, Golbik, Ralph, Sippl, Wolfgang, Zierz, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830186/
https://www.ncbi.nlm.nih.gov/pubmed/27123472
http://dx.doi.org/10.1212/NXG.0000000000000053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830186/
https://www.ncbi.nlm.nih.gov/pubmed/27123472
http://dx.doi.org/10.1212/NXG.0000000000000053

Ejemplares similares