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Bidirectional Modulation of Numerical Magnitude
Numerical cognition is critical for modern life; however, the precise neural mechanisms underpinning numerical magnitude allocation in humans remain obscure. Based upon previous reports demonstrating the close behavioral and neuro-anatomical relationship between number allocation and spatial attenti...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830300/ https://www.ncbi.nlm.nih.gov/pubmed/26879093 http://dx.doi.org/10.1093/cercor/bhv344 |
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author | Arshad, Qadeer Nigmatullina, Yuliya Nigmatullin, Ramil Asavarut, Paladd Goga, Usman Khan, Sarah Sander, Kaija Siddiqui, Shuaib Roberts, R. E. Cohen Kadosh, Roi Bronstein, Adolfo M. Malhotra, Paresh A. |
author_facet | Arshad, Qadeer Nigmatullina, Yuliya Nigmatullin, Ramil Asavarut, Paladd Goga, Usman Khan, Sarah Sander, Kaija Siddiqui, Shuaib Roberts, R. E. Cohen Kadosh, Roi Bronstein, Adolfo M. Malhotra, Paresh A. |
author_sort | Arshad, Qadeer |
collection | PubMed |
description | Numerical cognition is critical for modern life; however, the precise neural mechanisms underpinning numerical magnitude allocation in humans remain obscure. Based upon previous reports demonstrating the close behavioral and neuro-anatomical relationship between number allocation and spatial attention, we hypothesized that these systems would be subject to similar control mechanisms, namely dynamic interhemispheric competition. We employed a physiological paradigm, combining visual and vestibular stimulation, to induce interhemispheric conflict and subsequent unihemispheric inhibition, as confirmed by transcranial direct current stimulation (tDCS). This allowed us to demonstrate the first systematic bidirectional modulation of numerical magnitude toward either higher or lower numbers, independently of either eye movements or spatial attention mediated biases. We incorporated both our findings and those from the most widely accepted theoretical framework for numerical cognition to present a novel unifying computational model that describes how numerical magnitude allocation is subject to dynamic interhemispheric competition. That is, numerical allocation is continually updated in a contextual manner based upon relative magnitude, with the right hemisphere responsible for smaller magnitudes and the left hemisphere for larger magnitudes. |
format | Online Article Text |
id | pubmed-4830300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48303002016-04-14 Bidirectional Modulation of Numerical Magnitude Arshad, Qadeer Nigmatullina, Yuliya Nigmatullin, Ramil Asavarut, Paladd Goga, Usman Khan, Sarah Sander, Kaija Siddiqui, Shuaib Roberts, R. E. Cohen Kadosh, Roi Bronstein, Adolfo M. Malhotra, Paresh A. Cereb Cortex Articles Numerical cognition is critical for modern life; however, the precise neural mechanisms underpinning numerical magnitude allocation in humans remain obscure. Based upon previous reports demonstrating the close behavioral and neuro-anatomical relationship between number allocation and spatial attention, we hypothesized that these systems would be subject to similar control mechanisms, namely dynamic interhemispheric competition. We employed a physiological paradigm, combining visual and vestibular stimulation, to induce interhemispheric conflict and subsequent unihemispheric inhibition, as confirmed by transcranial direct current stimulation (tDCS). This allowed us to demonstrate the first systematic bidirectional modulation of numerical magnitude toward either higher or lower numbers, independently of either eye movements or spatial attention mediated biases. We incorporated both our findings and those from the most widely accepted theoretical framework for numerical cognition to present a novel unifying computational model that describes how numerical magnitude allocation is subject to dynamic interhemispheric competition. That is, numerical allocation is continually updated in a contextual manner based upon relative magnitude, with the right hemisphere responsible for smaller magnitudes and the left hemisphere for larger magnitudes. Oxford University Press 2016-05 2016-02-14 /pmc/articles/PMC4830300/ /pubmed/26879093 http://dx.doi.org/10.1093/cercor/bhv344 Text en © The Author 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Arshad, Qadeer Nigmatullina, Yuliya Nigmatullin, Ramil Asavarut, Paladd Goga, Usman Khan, Sarah Sander, Kaija Siddiqui, Shuaib Roberts, R. E. Cohen Kadosh, Roi Bronstein, Adolfo M. Malhotra, Paresh A. Bidirectional Modulation of Numerical Magnitude |
title | Bidirectional Modulation of Numerical Magnitude |
title_full | Bidirectional Modulation of Numerical Magnitude |
title_fullStr | Bidirectional Modulation of Numerical Magnitude |
title_full_unstemmed | Bidirectional Modulation of Numerical Magnitude |
title_short | Bidirectional Modulation of Numerical Magnitude |
title_sort | bidirectional modulation of numerical magnitude |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830300/ https://www.ncbi.nlm.nih.gov/pubmed/26879093 http://dx.doi.org/10.1093/cercor/bhv344 |
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