Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture

Colorectal cancer (CRC) is one of the top three cancer-related causes of death worldwide. FBXW7 is a known tumor-suppressor gene, commonly mutated in CRC and in a variety of other epithelial tumors. Low expression of FBXW7 is also associated with poor prognosis. Loss of FBXW7 sensitizes cancer cells...

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Detalles Bibliográficos
Autores principales: Lorenzi, Federica, Babaei-Jadidi, Roya, Sheard, Jonathan, Spencer-Dene, Bradley, Nateri, Abdolrahman S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830362/
https://www.ncbi.nlm.nih.gov/pubmed/27110583
http://dx.doi.org/10.1038/mtm.2016.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830362/
https://www.ncbi.nlm.nih.gov/pubmed/27110583
http://dx.doi.org/10.1038/mtm.2016.24

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