Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice

PURPOSE: Optic neuritis affects most patients with multiple sclerosis (MS), and current treatments are unreliable. The purpose of this study was to characterize the contribution of Th1 and Th17 cells to the development of optic neuritis. METHODS: Mice were passively transferred myelin-specific Th1 o...

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Detalles Bibliográficos
Autores principales: Larabee, Chelsea M., Hu, Yang, Desai, Shruti, Georgescu, Constantin, Wren, Jonathan D., Axtell, Robert C., Plafker, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830397/
https://www.ncbi.nlm.nih.gov/pubmed/27122964

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