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Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation

The nerve growth factor NGF has been shown to cause cell fate decisions toward either differentiation or proliferation depending on the relative activity of downstream pERK, pAKT, or pJNK signaling. However, how these protein signals are translated into and fed back from transcriptional activity to...

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Detalles Bibliográficos
Autores principales:	Offermann, Barbara, Knauer, Steffen, Singh, Amit, Fernández-Cachón, María L., Klose, Martin, Kowar, Silke, Busch, Hauke, Boerries, Melanie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830832/ https://www.ncbi.nlm.nih.gov/pubmed/27148350 http://dx.doi.org/10.3389/fgene.2016.00044

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